Publication Name	World Journal of Gastroenterology
Manuscript ID	41562
Country	China

Received	2018-08-14 08:52
Peer-Review Started	2018-08-15 00:56
To Make the First Decision	2018-10-08 02:32
Return for Revision	2018-10-10 09:14
Revised	2018-10-22 06:00
Second Decision	2018-11-07 09:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-11-08 02:38
Articles in Press	2018-11-08 02:38
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-11-18 09:44
Typeset the Manuscript	2018-12-06 03:26
Publish the Manuscript Online	2018-12-07 03:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Virology
Manuscript Type	Basic Study
Article Title	Neonatal rhesus monkeys as an animal model for rotavirus infection
Manuscript Source	Unsolicited Manuscript
All Author List	Na Yin, Feng-Mei Yang, Hong-Tu Qiao, Yan Zhou, Su-Qin Duan, Xiao-Chen Lin, Jin-Yuan Wu, Yu-Ping Xie, Zhan-Long He, Mao-Sheng Sun and Hong-Jun Li
ORCID	Author(s) ORCID Number Na Yin http://orcid.org/0000-0002-9816-2854 Feng-Mei Yang http://orcid.org/0000-0002-7695-7453 Hong-Tu Qiao http://orcid.org/0000-0002-6965-8391 Yan Zhou http://orcid.org/0000-0002-1802-5244 Su-Qin Duan http://orcid.org/0000-0002-7685-1691 Xiao-Chen Lin http://orcid.org/0000-0003-4249-6879 Jin-Yuan Wu http://orcid.org/0000-0001-6125-1821 Yu-Ping Xie http://orcid.org/0000-0002-5696-2239 Zhan-Long He http://orcid.org/0000-0002-7436-1509 Mao-Sheng Sun http://orcid.org/0000-0002-8575-5079 Hong-Jun Li http://orcid.org/0000-0001-6941-9852
Funding Agency and Grant Number	Funding Agency Grant Number CAMS Initiative for Innovative Medicine 2016-I2M-1-019 National Natural Science Foundation of China 31700154 Major Science and Technology Special Project of Yunnan Province (Biomedicine) 2018ZF006 Science and Technology Project of Yunnan Province—general program 2016FB034 Science and Technology Innovation Team Project of Kunming 2016-2-R-07674 The Project of National Nonprofit Scientific Institutes Basic Scientific Service Fee 2016ZX310179-4 Science and Technology Project of Yunnan Province - Key New Product Development 2014BC008
Corresponding Author	Hong-Jun Li, PhD, Academic Research, Department of Molecular Biology, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, No. 935 Jiaoling Rd, Kunming 650118, Yunnan Province, China. lihj6912@163.com
Key Words	Rotavirus; Neonatal rhesus monkey; Animal model; Infection; Diarrhea
Core Tip	Rotavirus (RV) is one of the main pathogens responsible for severe diarrhea in children under 5 years of age. Vaccine-induced immunity is an effective way to block RV disease. Nonhuman primates are the animals most closely related to humans and have advantages over non-primates as an animal model of RV diarrhea, so development of a nonhuman primate animal model of RV infection is needed to ensure the effectiveness and safety of these vaccines. Our current study has indicated that RV SA11 can lead to obvious diarrhea and pathological changes in the intestine of neonatal rhesus monkeys. The RV infection model we established is useful for us to further investigate the RV infection mechanism and the associated immune mechanisms in human infants and evaluate the cross protection of potential HRV vaccine candidates.
Publish Date	2018-12-07 03:57
Citation	Yin N, Yang FM, Qiao HT, Zhou Y, Duan SQ, Lin XC, Wu JY, Xie YP, He ZL, Sun MS, Li HJ. Neonatal rhesus monkeys as an animal model for rotavirus infection. World J Gastroenterol 2018; 24(45): 5109-5119
URL	http://www.wjgnet.com/1007-9327/full/v24/i45/5109.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i45.5109

Full Article (PDF)	WJG-24-5109.pdf
Full Article (Word)	WJG-24-5109.doc
The ARRIVE Guidelines	41562-The ARRIVE guidelines.pdf
Manuscript File	41562-Review.docx
Answering Reviewers	41562-Answering reviewers.pdf
Audio Core Tip	41562-Audio core tip.m4a
Biostatistics Review Certificate	41562-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	41562-Conflict-of-interest statement.pdf
Copyright License Agreement	41562-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	41562-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	41562-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	41562-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	41562-Language certificate.pdf
Supplementary Material	41562-Supplementary material.pdf
Peer-review Report	41562-Peer-review(s).pdf
Scientific Misconduct Check	41562-Scientific misconduct check.pdf
Scientific Editor Work List	41562-Scientific editor work list.pdf