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12/7/2018 3:57:11 AM | Browse: 222 | Download: 252
Publication Name World Journal of Gastroenterology
Manuscript ID 41562
Country of Manuscript Source China
2018-08-14 08:52
Peer-Review Started
2018-08-15 00:56
To Make the First Decision
2018-10-08 02:32
Return for Revision
2018-10-10 09:14
2018-10-22 06:00
Second Decision
2018-11-07 09:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-08 02:38
Articles in Press
2018-11-08 02:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-11-18 09:44
Typeset the Manuscript
2018-12-06 03:26
Publish the Manuscript Online
2018-12-07 03:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Basic Study
Article Title Neonatal rhesus monkeys as an animal model for rotavirus infection
Manuscript Source Unsolicited Manuscript
All Author List Na Yin, Feng-Mei Yang, Hong-Tu Qiao, Yan Zhou, Su-Qin Duan, Xiao-Chen Lin, Jin-Yuan Wu, Yu-Ping Xie, Zhan-Long He, Mao-Sheng Sun and Hong-Jun Li
Author(s) ORCID Number
Na Yin http://orcid.org/0000-0002-9816-2854
Feng-Mei Yang http://orcid.org/0000-0002-7695-7453
Hong-Tu Qiao http://orcid.org/0000-0002-6965-8391
Yan Zhou http://orcid.org/0000-0002-1802-5244
Su-Qin Duan http://orcid.org/0000-0002-7685-1691
Xiao-Chen Lin http://orcid.org/0000-0003-4249-6879
Jin-Yuan Wu http://orcid.org/0000-0001-6125-1821
Yu-Ping Xie http://orcid.org/0000-0002-5696-2239
Zhan-Long He http://orcid.org/0000-0002-7436-1509
Mao-Sheng Sun http://orcid.org/0000-0002-8575-5079
Hong-Jun Li http://orcid.org/0000-0001-6941-9852
Funding Agency and Grant Number
Funding Agency Grant Number
CAMS Initiative for Innovative Medicine 2016-I2M-1-019
National Natural Science Foundation of China 31700154
Major Science and Technology Special Project of Yunnan Province (Biomedicine) 2018ZF006
Science and Technology Project of Yunnan Province—general program 2016FB034
Science and Technology Innovation Team Project of Kunming 2016-2-R-07674
The Project of National Nonprofit Scientific Institutes Basic Scientific Service Fee 2016ZX310179-4
Science and Technology Project of Yunnan Province - Key New Product Development 2014BC008
Corresponding author Hong-Jun Li, PhD, Academic Research, Department of Molecular Biology, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, No. 935 Jiaoling Rd, Kunming 650118, China. lihj6912@163.com
Keywords Rotavirus; Neonatal rhesus monkey; Animal model; Infection; Diarrhea
Core Tip Rotavirus (RV) is one of the main pathogens responsible for severe diarrhea in children under 5 years of age. Vaccine-induced immunity is an effective way to block RV disease. Nonhuman primates are the animals most closely related to humans and have advantages over non-primates as an animal model of RV diarrhea, so development of a nonhuman primate animal model of RV infection is needed to ensure the effectiveness and safety of these vaccines. Our current study has indicated that RV SA11 can lead to obvious diarrhea and pathological changes in the intestine of neonatal rhesus monkeys. The RV infection model we established is useful for us to further investigate the RV infection mechanism and the associated immune mechanisms in human infants and evaluate the cross protection of potential HRV vaccine candidates.
Publish Date 2018-12-07 03:57
Citation Yin N, Yang FM, Qiao HT, Zhou Y, Duan SQ, Lin XC, Wu JY, Xie YP, He ZL, Sun MS, Li HJ. Neonatal rhesus monkeys as an animal model for rotavirus infection. World J Gastroenterol 2018; 24(45): 5109-5119
Url http://www.wjgnet.com/1007-9327/full/v24/i45/5109.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i45.5109
Full Article (PDF) WJG-24-5109.pdf
Full Article (Word) WJG-24-5109.doc
Manuscript File 41562-Review.docx
Answering Reviewers 41562-Answering reviewers.pdf
Audio Core Tip 41562-Audio core tip.m4a
Biostatistics Review Certificate 41562-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 41562-Conflict-of-interest statement.pdf
Copyright License Agreement 41562-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 41562-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 41562-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 41562-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 41562-Language certificate.pdf
Supplementary Material 41562-Supplementary material.pdf
Peer-review Report 41562-Peer-review(s).pdf
Scientific Misconduct Check 41562-Scientific misconduct check.pdf
Scientific Editor Work List 41562-Scientific editor work list.pdf