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Articles Published Processes
11/27/2018 5:55:53 AM | Browse: 1101 | Download: 1471
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Received |
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2018-08-28 02:29 |
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Peer-Review Started |
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2018-08-28 07:43 |
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To Make the First Decision |
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2018-10-08 02:35 |
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Return for Revision |
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2018-10-09 03:50 |
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Revised |
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2018-10-24 19:51 |
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Second Decision |
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2018-11-02 09:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-11-02 17:00 |
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Articles in Press |
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2018-11-02 17:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-11-27 01:58 |
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Publish the Manuscript Online |
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2018-11-27 05:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Glutathione depleting drugs, antioxidants and intestinal calcium absorption
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Luciana Moine, Maria Rivoira, Gabriela Diaz de Barboza, Adriana Perez and Nori Tolosa de Talamoni |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nori Tolosa de Talamoni, PhD, Professor, Laboratorio “Dr. Fernando Cañas”, Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Pabellón Argentina, 2do. Piso, Ciudad Universitaria, Córdoba 5000, Argentina. ntolosa@biomed.fcm.unc.edu.ar |
| Key Words |
Glutathione; Transcellular and paracellular Ca2+pathways; DL-buthionine-S,R-sulfoximine; Fructose rich diet; Menadione; Sodium deoxycholate; Glutamine; Ursodeoxycholic acid; Melatonin; Quercetin; Naringin |
| Core Tip |
The normal content of glutathione (GSH) in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. |
| Publish Date |
2018-11-27 05:55 |
| Citation |
Moine L, Rivoira M, Díaz de Barboza G, Pérez A, Tolosa de Talamoni N. Glutathione depleting drugs, antioxidants and intestinal calcium absorption. World J Gastroenterol 2018; 24(44): 4979-4988 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i44/4979.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i44.4979 |
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