Publication Name	World Journal of Hypertension
Manuscript ID	4196
Country	Japan

Received	2013-06-21 09:15
Peer-Review Started	2013-06-21 16:37
To Make the First Decision	2013-07-05 18:20
Return for Revision	2013-07-15 22:49
Revised	2013-08-09 16:24
Second Decision	2013-08-20 12:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-20 13:45
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-26 13:51
Publish the Manuscript Online	2013-09-14 11:35

ISSN	2220-3168 (online)
Open Access
Copyright
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Autobiography
Article Title	Induction of tissue angiotensin Ⅱ-forming activity in two-kidney, one-clip hypertensive hamster model
Manuscript Source	Invited Manuscript
All Author List	Yoshinari Uehara, Kanta Fujimi, Eiji Yahiro, Satomi Abe, Sankar Devarajan, Keijiro Saku and Hidenori Urata
Funding Agency and Grant Number
Corresponding Author	Yoshinari Uehara, MD, PhD, Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. ueharay@fukuoka-u.ac.jp
Key Words	Chymase; Local renin angiotensin system; Angiotensin Ⅱ; Tissue remodeling; Hypertension
Core Tip	There are several pathways that can produce angiotensin (Ang) Ⅱ in human tissues, which are involved in remodeling of the cardiovascular system. Among these, chymase has been exhibited the greatest Ang Ⅱ-forming enzyme in human heart. In hypertensive hamster, blood pressure was significantly elevated, and both Ang converting enzyme (ACE) inhibitor (ACE-I) and Ang Ⅱ type 1 receptor antagonist (ARB) revealed similar antihypertensive effects. Interestingly, cardiac chymase-dependent Ang Ⅱ-formation decreased after ACE-I or ARB treatment. In addition, chymase-dependent Ang Ⅱ-formation increased in the aorta, although these changes were inhibited only by ARB. ACE and chymase were regulated in a tissue-dependent manner in hypertensive hamsters, and the both enzymes were independently regulated.
Publish Date	2013-09-14 11:35
Citation	Uehara Y, Fujimi K, Yahiro E, Abe S, Devarajan S, Saku K, Urata H. Induction of tissue angiotensin Ⅱ-forming activity in two-kidney, one-clip hypertensive hamster model. World J Hypertens 2013; 3(2): 9-17
URL	http://www.wjgnet.com/2220-3168/full/v3/i2/9.htm
DOI	http://dx.doi.org/10.5494/wjh.v3.i2.9

Full Article (PDF)	WJH-3-9.pdf
Manuscript File	4196-Review.docx
Answering Reviewers	4196-Answering reviewers.pdf
Copyright License Agreement	4196-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	4196-Language certificate.pdf
Peer-review Report	4196-Peer review(s).pdf
Scientific Editor Work List	4196-Scientific editor work list.doc