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1/2/2019 8:01:03 AM | Browse: 782 | Download: 996
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 42023
Country/Territory Australia
Received
2018-09-11 01:53
Peer-Review Started
2018-09-11 10:17
To Make the First Decision
2018-10-17 01:39
Return for Revision
2018-10-19 09:46
Revised
2018-10-30 23:32
Second Decision
2018-12-07 09:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-11 02:38
Articles in Press
2018-12-11 02:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-12-24 18:18
Typeset the Manuscript
2018-12-27 03:49
Publish the Manuscript Online
2019-01-02 08:01
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Current therapies and novel approaches for biliary diseases
Manuscript Source Invited Manuscript
All Author List Indu G Rajapaksha, Peter W Angus and Chandana B Herath
ORCID
Author(s) ORCID Number
Indu G Rajapaksha http://orcid.org/0000-0002-4403-7177
Peter W Angus http://orcid.org/0000-0001-8505-2317
Chandana B Herath http://orcid.org/0000-0001-9151-8531
Funding Agency and Grant Number
Corresponding Author Chandana B Herath, PhD, Senior Research Fellow, Department of Medicine, The University of Melbourne, Level 7, LTB, Austin Health, Heidelberg 3084, VIC, Australia. cherath@unimelb.edu.au
Key Words Chronic liver disease; Biliary fibrosis; Current therapies for biliary fibrosis; Angiotensin converting enzyme-2; Gene therapy
Core Tip This mini-review focuses on the pathophysiology of chronic liver fibrosis, with a special emphasis on biliary fibrosis. We also attempted to provide information on current clinically available therapeutic options for biliary fibrosis and other potential therapeutic options that are in the preclinical stage of development, and discuss their advantages and disadvantages. In particular, work from the author’s laboratory described in this review indicates that liver-specific over-expression of angiotensin converting enzyme-2 (known as ACE2) of the alternate renin angiotensin system dramatically reduces biliary fibrosis in mouse models of biliary disease. This suggests that ACE2 gene therapy has the potential to treat patients with chronic biliary fibrosis.
Publish Date 2019-01-02 08:01
Citation Rajapaksha IG, Angus PW, Herath CB. Current therapies and novel approaches for biliary diseases. World J Gastrointest Pathophysiol 2019; 10(1): 1-10
URL https://www.wjgnet.com/2150-5330/full/v10/i1/1.htm
DOI https://dx.doi.org/10.4291/wjgp.v10.i1.1
Full Article (PDF) WJGP-10-1.pdf
Full Article (Word) WJGP-10-1.docx
Manuscript File 42023-Review.docx
Answering Reviewers 42023-Answering reviewers.pdf
Audio Core Tip 42023-Audio core tip.aac
Conflict-of-Interest Disclosure Form 42023-Conflict-of-interest statement.pdf
Copyright License Agreement 42023-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42023-Grant application form(s).pdf
Peer-review Report 42023-Peer-review(s).pdf
Scientific Misconduct Check 42023-Scientific misconduct check.pdf
Scientific Editor Work List 42023-Scientific editor work list.pdf