Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	42023
Country	Australia

Received	2018-09-11 01:53
Peer-Review Started	2018-09-11 10:17
To Make the First Decision	2018-10-17 01:39
Return for Revision	2018-10-19 09:46
Revised	2018-10-30 23:32
Second Decision	2018-12-07 09:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-12-11 02:38
Articles in Press	2018-12-11 02:38
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-12-24 18:18
Typeset the Manuscript	2018-12-27 03:49
Publish the Manuscript Online	2019-01-02 08:01

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Current therapies and novel approaches for biliary diseases
Manuscript Source	Invited Manuscript
All Author List	Indu G Rajapaksha, Peter W Angus and Chandana B Herath
ORCID	Author(s) ORCID Number Indu G Rajapaksha http://orcid.org/0000-0002-4403-7177 Peter W Angus http://orcid.org/0000-0001-8505-2317 Chandana B Herath http://orcid.org/0000-0001-9151-8531
Funding Agency and Grant Number
Corresponding Author	Chandana B Herath, PhD, Senior Research Fellow, Department of Medicine, The University of Melbourne, Level 7, LTB, Austin Health, Heidelberg 3084, VIC, Australia. cherath@unimelb.edu.au
Key Words	Chronic liver disease; Biliary fibrosis; Current therapies for biliary fibrosis; Angiotensin converting enzyme-2; Gene therapy
Core Tip	This mini-review focuses on the pathophysiology of chronic liver fibrosis, with a special emphasis on biliary fibrosis. We also attempted to provide information on current clinically available therapeutic options for biliary fibrosis and other potential therapeutic options that are in the preclinical stage of development, and discuss their advantages and disadvantages. In particular, work from the author’s laboratory described in this review indicates that liver-specific over-expression of angiotensin converting enzyme-2 (known as ACE2) of the alternate renin angiotensin system dramatically reduces biliary fibrosis in mouse models of biliary disease. This suggests that ACE2 gene therapy has the potential to treat patients with chronic biliary fibrosis.
Publish Date	2019-01-02 08:01
Citation	Rajapaksha IG, Angus PW, Herath CB. Current therapies and novel approaches for biliary diseases. World J Gastrointest Pathophysiol 2019; 10(1): 1-10
URL	https://www.wjgnet.com/2150-5330/full/v10/i1/1.htm
DOI	https://dx.doi.org/10.4291/wjgp.v10.i1.1

Full Article (PDF)	WJGP-10-1.pdf
Full Article (Word)	WJGP-10-1.docx
Manuscript File	42023-Review.docx
Answering Reviewers	42023-Answering reviewers.pdf
Audio Core Tip	42023-Audio core tip.aac
Conflict-of-Interest Disclosure Form	42023-Conflict-of-interest statement.pdf
Copyright License Agreement	42023-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	42023-Grant application form(s).pdf
Peer-review Report	42023-Peer-review(s).pdf
Scientific Misconduct Check	42023-Scientific misconduct check.pdf
Scientific Editor Work List	42023-Scientific editor work list.pdf