Publication Name	World Journal of Hepatology
Manuscript ID	42196
Country	Japan

Received	2018-09-13 07:59
Peer-Review Started	2018-09-13 12:52
To Make the First Decision	2018-10-08 03:37
Return for Revision	2018-10-09 10:06
Revised	2018-11-08 07:18
Second Decision	2018-11-14 11:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-11-16 06:08
Articles in Press	2018-11-16 06:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-12-25 00:56
Publish the Manuscript Online	2018-12-27 09:28

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Hepatitis C virus-associated hepatocellular carcinoma after sustained virologic response
Manuscript Source	Invited Manuscript
All Author List	Reina Sasaki, Tatsuo Kanda, Naoya Kato, Osamu Yokosuka and Mitsuhiko Moriyama
ORCID	Author(s) ORCID Number Reina Sasaki http://orcid.org/0000-0002-5968-8124 Tatsuo Kanda http://orcid.org/0000-0002-9565-4669 Naoya Kato http://orcid.org/0000-0001-5812-2818 Osamu Yokosuka http://orcid.org/0000-0002-1763-9439 Mitsuhiko Moriyama http://orcid.org/0000-0002-4617-508X
Funding Agency and Grant Number
Corresponding Author	Tatsuo Kanda, MD, PhD, Associate Professor, Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku 173-8610, Tokyo, Japan. kandat-cib@umin.ac.jp
Key Words	Hepatitis C virus; Hepatocellular carcinoma; Sustained virologic response; Direct-acting antiviral agents
Core Tip	The incidence of hepatocellular carcinoma (HCC) in hepatitis C virus (HCV) patients with sustained virologic response (SVR) after direct-acting antiviral (DAA) treatment is a serious health issue. We focused on the role of DAA treatment in hepatocarcinogenesis. DAAs may also lead to rapid changes in immune status through interactions between the host and HCV. Changes in the immune system may play a role in the progression of HCC. Further observations are needed to determine the effects on hepatocarcinogenesis caused by the eradication of HCV with DAAs.
Publish Date	2018-12-27 09:28
Citation	Sasaki R, Kanda T, Kato N, Yokosuka O, Moriyama M. Hepatitis C virus-associated hepatocellular carcinoma after sustained virologic response. World J Hepatol 2018; 10(12): 898-906
URL	https://www.wjgnet.com/1948-5182/full/v10/i12/898.htm
DOI	https://dx.doi.org/10.4254/wjh.v10.i12.898

Full Article (PDF)	WJH-10-898.pdf
Full Article (Word)	WJH-10-898.doc
Manuscript File	42196-Review.docx
Answering Reviewers	42196-Answering reviewers.pdf
Audio Core Tip	42196-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	42196-Conflict-of-interest statement.pdf
Copyright License Agreement	42196-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	42196-Language certificate.pdf
Peer-review Report	42196-Peer-review(s).pdf
Scientific Misconduct Check	42196-Scientific misconduct check.pdf
Scientific Editor Work List	42196-Scientific editor work list.pdf