| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dbx2 performs a tumor-promoting function in hepatocellular carcinoma cell lines via regulating the Shh-Gli1 pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Ting Hu, Bei-Fang Li, Peng-Jun Zhang, Di Wu, Yan-Yan Li, Zhong-Wu Li, Lin Shen, Jing Gao, Bin Dong and Xu Zhu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81571781 |
|
| Corresponding Author |
Xu Zhu, MD, PhD, Doctor, Doctor, Professor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Interventional Therapy, Peking University Cancer Hospital and Institute, No. 52, Fucheng Road, Haidian District, Beijing 100214, China. drzhuxu@163.com |
| Key Words |
Developing brain homeobox 2; Hepatocellular carcinoma; Sonic Hedgehog pathway; Expression; Tumor tissues |
| Core Tip |
Core tip: Developing brain homeobox 2 (Dbx2) plays an important role in cell differentiation and is frequently upregulated in tumor tissues, while its function in hepatocellular carcinoma (HCC) has not been reported. Our results indicate that Dbx2 significantly upregulated in HCC tissues and strongly correlated with tumor size. Subsequently, both gain and loss of function assays indicated that Dbx2 promoted HCC migration, invasion and proliferation by facilitating the transition from G1 to S, attenuating apoptosis in vitro and in vivo. Mechanistically, Dbx2 modulated sonic hedgehog (Shh) signaling by enhancing FTCH1 and GLi1 expression in HCC cells. |
| Publish Date |
2019-02-27 04:11 |
| Citation |
Hu YT, Li BF, Zhang PJ, Wu D, Li YY, Li ZW, Shen L, Dong B, Gao J, Zhu X. Dbx2 exhibits a tumor-promoting role in hepatocellular carcinoma cell lines via regulating Shh-Gli1 signaling. World J Gastroenterol 2019; 25(8): 923-940 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i8/923.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i8.923 |
