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12/13/2018 6:32:35 AM | Browse: 199 | Download: 273
Publication Name World Journal of Gastroenterology
Manuscript ID 42352
Country/Territory Spain
Received
2018-09-19 05:55
Peer-Review Started
2018-09-19 06:55
To Make the First Decision
2018-11-01 06:53
Return for Revision
2018-11-01 09:01
Revised
2018-11-13 09:49
Second Decision
2018-11-16 07:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-16 18:39
Articles in Press
2018-11-16 18:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-12-12 03:43
Publish the Manuscript Online
2018-12-13 06:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Modulation of faecal metagenome in Crohn’s disease: Role of microRNAs as biomarkers
Manuscript Source Invited Manuscript
All Author List María Rojas-Feria, Teresa Romero-García, Jose Ángel Fernández Caballero-Rico, Helena Pastor-Ramírez, Marta Avilés-Recio, Manuel Castro-Fernández, Natalia Chueca-Porcuna, Manuel Romero-Gómez, Federico Garcia, Lourdes Grande and José A Del Campo
ORCID
Author(s) ORCID Number
María Rojas-Feria http://orcid.org/0000-0002-1815-1195
Teresa Romero-García http://orcid.org/0000-0002-7093-5982
Jose Ángel Fernández Caballero-Rico http://orcid.org/0000-0003-0239-961X
Helena Pastor-Ramírez http://orcid.org/0000-0003-2975-3973
Marta Avilés-Recio http://orcid.org/0000-0002-1956-6122
Manuel Castro-Fernández http://orcid.org/0000-0001-9585-1593
Natalia Chueca-Porcuna http://orcid.org/0000-0002-3420-3290
Manuel Romero-Gómez http://orcid.org/0000-0001-8494-8947
Federico Garcia http://orcid.org/0000-0002-8548-1768
Lourdes Grande http://orcid.org/0000-0001-7685-0464
José A Del Campo http://orcid.org/0000-0002-6037-1028
Funding Agency and Grant Number
Funding Agency Grant Number
Instituto de Salud Carlos III PI14/01349
Corresponding author José A Del Campo, PhD, Senior Scientist, Department of Digestive Diseases, Valme University Hospital, UGC Digestive Disease and CIBERehd, Avda. Bellvista s/n, Sevilla E-41014, Spain. jantonio.delcampo@ciberehd.org
Keywords Crohn’s disease; Dysbiosis; microRNAs; Firmicutes; Bacteroidetes
Core Tip In this study, we have found a shift in microbial gut community composition that supports dysbiosis in Crohn’s disease (CD) patients. The greatest interest of our work is that we have only included new-onset adult CD patients. We found that active non-treated CD patients had a low Firmicutes/Bacteroidetes ratio, less biodiversity in the structure of microbial communities and a significantly different pattern on gut microbiota distri­bution. Three microRNAs (miRNAs) have been found induced in affected mucosa vs non-affected mucosa in CD, indicating that miRNA profile may serve as biomarker for active disease.
Publish Date 2018-12-13 06:32
Citation Rojas-Feria M, Romero-García T, Fernández Caballero-Rico JÁ, Pastor Ramírez H, Avilés-Recio M, Castro-Fernandez M, Chueca Porcuna N, Romero-Gόmez M, García F, Grande L, Del Campo JA. Modulation of faecal metagenome in Crohn’s disease: Role of microRNAs as biomarkers. World J Gastroenterol 2018; 24(46): 5223-5233
Url https://www.wjgnet.com/1007-9327/full/v24/i46/5223.htm
DOI https://dx.doi.org/10.3748/wjg.v24.i46.5223
Full Article (PDF) WJG-24-5223.pdf
Full Article (Word) WJG-24-5223.docx
Manuscript File 42352-Review.docx
Answering Reviewers 42352-Answering reviewers.pdf
Audio Core Tip 42352-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 42352-Conflict-of-interest statement.pdf
Copyright License Agreement 42352-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42352-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 42352-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 42352-Language certificate.pdf
Peer-review Report 42352-Peer-review(s).pdf
Scientific Misconduct Check 42352-Scientific misconduct check.pdf
Scientific Editor Work List 42352-Scientific editor work list.pdf