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Articles Published Processes
12/13/2018 6:32:35 AM | Browse: 1000 | Download: 1835
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Received |
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2018-09-19 05:55 |
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Peer-Review Started |
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2018-09-19 06:55 |
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To Make the First Decision |
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2018-11-01 06:53 |
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Return for Revision |
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2018-11-01 09:01 |
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Revised |
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2018-11-13 09:49 |
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Second Decision |
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2018-11-16 07:29 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-11-16 18:39 |
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Articles in Press |
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2018-11-16 18:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-12-12 03:43 |
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Publish the Manuscript Online |
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2018-12-13 06:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Modulation of faecal metagenome in Crohn’s disease: Role of microRNAs as biomarkers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
María Rojas-Feria, Teresa Romero-García, Jose Ángel Fernández Caballero-Rico, Helena Pastor-Ramírez, Marta Avilés-Recio, Manuel Castro-Fernández, Natalia Chueca-Porcuna, Manuel Romero-Gómez, Federico Garcia, Lourdes Grande and José A Del Campo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Instituto de Salud Carlos III |
PI14/01349 |
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| Corresponding Author |
José A Del Campo, PhD, Senior Scientist, Department of Digestive Diseases, Valme University Hospital, UGC Digestive Disease and CIBERehd, Avda. Bellvista s/n, Sevilla E-41014, Spain. jantonio.delcampo@ciberehd.org |
| Key Words |
Crohn’s disease; Dysbiosis; microRNAs; Firmicutes; Bacteroidetes |
| Core Tip |
In this study, we have found a shift in microbial gut community composition that supports dysbiosis in Crohn’s disease (CD) patients. The greatest interest of our work is that we have only included new-onset adult CD patients. We found that active non-treated CD patients had a low Firmicutes/Bacteroidetes ratio, less biodiversity in the structure of microbial communities and a significantly different pattern on gut microbiota distribution. Three microRNAs (miRNAs) have been found induced in affected mucosa vs non-affected mucosa in CD, indicating that miRNA profile may serve as biomarker for active disease. |
| Publish Date |
2018-12-13 06:32 |
| Citation |
Rojas-Feria M, Romero-García T, Fernández Caballero-Rico JÁ, Pastor Ramírez H, Avilés-Recio M, Castro-Fernandez M, Chueca Porcuna N, Romero-Gόmez M, García F, Grande L, Del Campo JA. Modulation of faecal metagenome in Crohn’s disease: Role of microRNAs as biomarkers. World J Gastroenterol 2018; 24(46): 5223-5233 |
| URL |
https://www.wjgnet.com/1007-9327/full/v24/i46/5223.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v24.i46.5223 |
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