Publication Name	World Journal of Gastroenterology
Manuscript ID	42419
Country	Israel

Received	2018-09-30 09:46
Peer-Review Started	2018-09-30 14:55
First Decision by Editorial Office Director	2018-10-16 20:27
Return for Revision	2018-10-23 02:32
Revised	2018-10-31 21:39
Publication Fee Transferred
Second Decision by Editor	2018-11-09 08:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2018-11-09 18:04
Articles in Press	2018-11-09 18:04
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-12-06 03:26
Publish the Manuscript Online	2018-12-07 03:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model
Manuscript Source	Unsolicited Manuscript
All Author List	Karen Jackson, Noa Dressler, Rotem S. Ben-Shushan, Ari Meerson, Tyler W LeBaron and Snait Tamir
ORCID	Author(s) ORCID Number Karen Jackson http://orcid.org/0000-0001-5696-6224 Noa Dressler http://orcid.org/0000-0002-7636-3110 Rotem S. Ben-Shushan http://orcid.org/0000-0003-1240-5630 Ari Meerson http://orcid.org/(0000-0002-5811-7952 Tyler W LeBaron http://orcid.org/0000-0001-9164-6728 Snait Tamir http://orcid.org/0000-0002-7473-7369
Funding Agency and Grant Number	Funding Agency Grant Number Tel Hai College Research funding Grant 25-2-14-114
Corresponding Author	Karen Jackson, PhD, Academic Research, Assistant Lecturer, Research Scientist, Senior Lecturer, Senior Researcher, Laboratory of Human Health and Nutrition Sciences, MIGAL-Galilee Research Institute, POB 831, Kyriat Shmona 11016, Israel. karen@migal.org.il
Key Words	Hydrogen-rich-water; Nonalcoholic fatty liver disease; Alkaline water; Metabolic syndrome; Molecular hydrogen; High-fat diet
Core Tip	In this work, we compared the effects of two functional waters: Electrolyzed alkaline water and Hydrogen-rich water in a high-fat-diet-induced nonalcoholic fatty liver disease (NAFLD) mouse model. Hydrogen-rich water (HRW) has potential for NAFLD treatment by attenuating hepatic lipid accumulation, inflammation, and CD36 expression. However, neither electrolyzed-alkaline water (EAW) nor HRW with a low H2 concentration had protective effects on NAFLD. Additionally, we demonstrated that H2 pretreatment has a protective effect by modifying gene expression. The results demonstrate that H2 has a surprisingly positive impact in preventing NAFLD in mice and is also the key agent responsible in EAW for these benefits.
Publish Date	2018-12-07 03:57
Citation	Jackson K, Dressler N, Ben-Shushan RS, Meerson A, LeBaron TW, Tamir S. Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model. World J Gastroenterol 2018; 24(45): 5095-5108
URL	http://www.wjgnet.com/1007-9327/full/v24/i45/5095.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i45.5095

Full Article (PDF)	WJG-24-5095.pdf
Full Article (Word)	WJG-24-5095.doc
The ARRIVE Guidelines	42419-The ARRIVE guidelines.pdf
Manuscript File	42419-Review.docx
Answering Reviewers	42419-Answering reviewers.pdf
Audio Core Tip	42419-Audio core tip.mp3
Biostatistics Review Certificate	42419-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	42419-Conflict-of-interest statement.pdf
Copyright License Agreement	42419-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	42419-Institutional animal care and use committee statementn.pdf
Institutional Review Board Approval Form or Document	42419-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	42419-Language certificate.pdf
Peer-review Report	42419-Peer-review(s).pdf
Scientific Misconduct Check	42419-Scientific misconduct check.pdf
Scientific Editor Work List	42419-Scientific editor work list.pdf