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12/7/2018 3:57:11 AM | Browse: 168 | Download: 122
Publication Name World Journal of Gastroenterology
Manuscript ID 42419
Country of Manuscript Source Israel
2018-09-30 09:46
Peer-Review Started
2018-09-30 14:55
To Make the First Decision
2018-10-17 00:48
Return for Revision
2018-10-23 02:32
2018-10-31 21:39
Second Decision
2018-11-09 08:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-09 18:04
Articles in Press
2018-11-09 18:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-12-06 03:26
Publish the Manuscript Online
2018-12-07 03:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model
Manuscript Source Unsolicited Manuscript
All Author List Karen Jackson, Noa Dressler, Rotem S. Ben-Shushan, Ari Meerson, Tyler W LeBaron and Snait Tamir
Author(s) ORCID Number
Karen Jackson http://orcid.org/0000-0001-5696-6224
Noa Dressler http://orcid.org/0000-0002-7636-3110
Rotem S. Ben-Shushan http://orcid.org/0000-0003-1240-5630
Ari Meerson http://orcid.org/(0000-0002-5811-7952
Tyler W LeBaron http://orcid.org/0000-0001-9164-6728
Snait Tamir http://orcid.org/0000-0002-7473-7369
Funding Agency and Grant Number
Funding Agency Grant Number
Tel Hai College Research funding Grant 25-2-14-114
Corresponding author Karen Jackson, PhD, Academic Research, Assistant Lecturer, Research Scientist, Senior Lecturer, Senior Researcher, Lecturer, Laboratory of Human Health and Nutrition Sciences, MIGAL-Galilee Research Institute, POB 831, Kyriat Shmona 11016, Israel. Karen@migal.org.il
Keywords Hydrogen-rich-water; Nonalcoholic fatty liver disease; Alkaline water; Metabolic syndrome; Molecular hydrogen; High-fat diet
Core Tip In this work, we compared the effects of two functional waters: Electrolyzed alkaline water and Hydrogen-rich water in a high-fat-diet-induced nonalcoholic fatty liver disease (NAFLD) mouse model. Hydrogen-rich water (HRW) has potential for NAFLD treatment by attenuating hepatic lipid accumulation, inflammation, and CD36 expression. However, neither electrolyzed-alkaline water (EAW) nor HRW with a low H2 concentration had protective effects on NAFLD. Additionally, we demonstrated that H2 pretreatment has a protective effect by modifying gene expression. The results demonstrate that H2 has a surprisingly positive impact in preventing NAFLD in mice and is also the key agent responsible in EAW for these benefits.
Publish Date 2018-12-07 03:57
Citation Jackson K, Dressler N, Ben-Shushan RS, Meerson A, LeBaron TW, Tamir S. Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model. World J Gastroenterol 2018; 24(45): 5095-5108
Url http://www.wjgnet.com/1007-9327/full/v24/i45/5095.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i45.5095
Full Article (PDF) WJG-24-5095.pdf
Full Article (Word) WJG-24-5095.doc
Manuscript File 42419-Review.docx
Answering Reviewers 42419-Answering reviewers.pdf
Audio Core Tip 42419-Audio core tip.mp3
Biostatistics Review Certificate 42419-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42419-Conflict-of-interest statement.pdf
Copyright License Agreement 42419-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42419-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 42419-Institutional animal care and use committee statementn.pdf
Institutional Review Board Approval Form or Document 42419-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 42419-Language certificate.pdf
Peer-review Report 42419-Peer-review(s).pdf
Scientific Misconduct Check 42419-Scientific misconduct check.pdf
Scientific Editor Work List 42419-Scientific editor work list.pdf