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Articles Published Processes
12/7/2018 3:57:11 AM | Browse: 1318 | Download: 2183
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Received |
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2018-09-30 09:46 |
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Peer-Review Started |
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2018-09-30 14:55 |
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To Make the First Decision |
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2018-10-17 00:48 |
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Return for Revision |
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2018-10-23 02:32 |
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Revised |
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2018-10-31 21:39 |
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Second Decision |
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2018-11-09 08:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-11-09 18:04 |
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Articles in Press |
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2018-11-09 18:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-12-06 03:26 |
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Publish the Manuscript Online |
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2018-12-07 03:57 |
ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Karen Jackson, Noa Dressler, Rotem S. Ben-Shushan, Ari Meerson, Tyler W LeBaron and Snait Tamir |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Tel Hai College Research funding Grant |
25-2-14-114 |
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Corresponding Author |
Karen Jackson, PhD, Academic Research, Assistant Lecturer, Research Scientist, Senior Lecturer, Senior Researcher, Laboratory of Human Health and Nutrition Sciences, MIGAL-Galilee Research Institute, POB 831, Kyriat Shmona 11016, Israel. karen@migal.org.il |
Key Words |
Hydrogen-rich-water; Nonalcoholic fatty liver disease; Alkaline water; Metabolic syndrome; Molecular hydrogen; High-fat diet |
Core Tip |
In this work, we compared the effects of two functional waters: Electrolyzed alkaline water and Hydrogen-rich water in a high-fat-diet-induced nonalcoholic fatty liver disease (NAFLD) mouse model. Hydrogen-rich water (HRW) has potential for NAFLD treatment by attenuating hepatic lipid accumulation, inflammation, and CD36 expression. However, neither electrolyzed-alkaline water (EAW) nor HRW with a low H2 concentration had protective effects on NAFLD. Additionally, we demonstrated that H2 pretreatment has a protective effect by modifying gene expression. The results demonstrate that H2 has a surprisingly positive impact in preventing NAFLD in mice and is also the key agent responsible in EAW for these benefits. |
Publish Date |
2018-12-07 03:57 |
Citation |
Jackson K, Dressler N, Ben-Shushan RS, Meerson A, LeBaron TW, Tamir S. Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model. World J Gastroenterol 2018; 24(45): 5095-5108 |
URL |
http://www.wjgnet.com/1007-9327/full/v24/i45/5095.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v24.i45.5095 |
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