| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Abdominal paracentesis drainage ameliorates severe acute pancreatitis in rats by regulating the polarization of peritoneal macrophages
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ruo-Hong Liu, Yi Wen, Hong-Yu Sun, Chun-Yu Liu, Yu-Fan Zhang, Yi Yang, Qi-Lin Huang, Jia-Jia Tang, Can-Chen Huang and Li-Jun Tang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81772001 |
| National Natural Science Foundation of China |
8177071311 |
| National Natural Science Foundation of China |
81502696 |
| National Clinical Key Subject of China |
41792113 |
| Technology Plan Program of Sichuan Provence |
2015SZ0229 |
| Technology Plan Program of Sichuan Provence |
2018JY0041 |
| Technology Plan Program of Sichuan Provence |
18YYJC0442 |
| Science and Technology development plan of Sichuan Province |
2016YJ0023 |
|
| Corresponding Author |
Li-Jun Tang, MD, PhD, Chief Doctor, Doctor, Doctor, PLA Center of General Surgery and Pancreatic Injury and Repair Key Laboratory of Sichuan Province, Chengdu Military General Hospital, No. 270 Tianhui Road, Rongdu Avenue, Jinniu, Chengdu 610083, Sichuan Province, China. tanglj2016@163.com |
| Key Words |
Abdominal paracentesis drainage; Peritoneal macrophages; Polarization; Severe acute pancreatitis |
| Core Tip |
In the present study, we provided evidence for the first time that abdominal paracentesis drainage (APD) ameliorates inflammation in rats with severe acute pancreatitis (SAP) by regulating peritoneal macrophage M2 polarization. The important findings are that: (1) by removing pancreatitis-associated ascitic fluids, APD could improve the inflammatory environment of the peritoneal cavity; (2) the improved environment in the peritoneal cavity could polarize peritoneal macrophages towards the M2 phenotype; and (3) APD could promote M2 polarization of macrophages in the pancreas of SAP model rats. These findings provide new insights into the mechanisms underlying the effectiveness of APD, which may advance the clinical use of APD to benefit patients with SAP. |
| Publish Date |
2018-12-07 03:57 |
| Citation |
Liu RH, Wen Y, Sun HY, Liu CY, Zhang YF, Yang Y, Huang QL, Tang JJ, Huang CC, Tang LJ. Abdominal paracentesis drainage ameliorates severe acute pancreatitis in rats by regulating the polarization of peritoneal macrophages. World J Gastroenterol 2018; 24(45): 5131-5143 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i45/5131.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i45.5131 |
