| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Relationship between KRAS mutation status, expression of RAS pathway signaling molecules, and the clinicopathological features and prognosis of patients with colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiang-Bin Wan, Ai-Qin Wang, Jian Cao, Zhi-Chuang Dong, Ning Li, Sen Yang, Miao-Miao Sun, Zhi Li and Su-Xia Luo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Henan Department of Science and Technology, China |
162102310317 |
|
| Corresponding Author |
Su-Xia Luo, MD, Professor, Department of Medical Oncology, the Affiliated Cancer Hospital of Zhengzhou University, No. 127 Dongming Road, Jinshui District, Zhengzhou 450008, Henan Province, China. luoxiasu@126.com |
| Key Words |
Colorectal cancer; KRAS gene; KRAS protein; BRAF protein; MEK protein; ERK protein |
| Core Tip |
The RAS signaling pathway plays a crucial role in the invasiveness and metastasis of tumor cells. In the study, we examined the relationship between the KRAS gene mutation status and the clinicopathological features and prognosis of colorectal cancer (CRC) patients and the expression of BRAF, MEK, and ERK proteins. We found that KRAS gene mutations does not affect downstream protein expression or the clinicopathological features of CRC. KRAS protein is associated with poor tumor differentiation, older age, and a risk of tumor recurrence. The results may contribute to our understanding the drug resistance in KRAS mutant CRC. |
| Publish Date |
2019-02-21 09:31 |
| Citation |
Wan XB, Wang AQ, Cao J, Dong ZC, Li N, Yang S, Sun MM, Li Z, Luo SX. Relationship between KRAS mutation status, expression of RAS pathway signaling molecules, and the clinicopathological features and prognosis of patients with colorectal cancer. World J Gastroenterol 2019; 25(7): 808-823 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i7/808.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i7.808 |
