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Articles Published Processes
12/27/2018 8:56:32 AM | Browse: 1070 | Download: 1320
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Received |
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2018-10-07 06:00 |
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Peer-Review Started |
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2018-10-07 08:43 |
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To Make the First Decision |
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2018-11-08 06:25 |
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Return for Revision |
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2018-11-08 07:36 |
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Revised |
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2018-11-13 11:22 |
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Second Decision |
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2018-11-16 07:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-11-16 18:45 |
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Articles in Press |
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2018-11-16 18:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-12-26 02:51 |
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Publish the Manuscript Online |
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2018-12-27 08:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer: An update
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rafael I Jaén, Patricia Prieto, Marta Casado, Paloma Martín-Sanz and Lisardo Boscá |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministerio de Ciencia Innovación y Universidades |
SAF2017-82436R, SAF2016-75004R |
| Comunidad de Madrid |
S2017/BMD-3686 |
| Fundación Ramón Areces |
2016/CIVP18A3864 |
| ISCIII-FEDER |
CIBERcv |
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| Corresponding Author |
Lisardo Boscá, BM BCh, PhD, Doctor, Doctor, Professor, Senior Research Fellow, Department of Metabolism and Physiopathology of Inflammatory Diseases, Instituto de Investigaciones Biomédicas Alberto Sols, Arturo Duperier 4, Madrid 28029, Spain. lbosca@iib.uam.es |
| Key Words |
Prostaglandins; Prostaglandin-endoperoxide synthase 2; Post-translational modifications; Glycosylation; Colorectal cancer; Inflammation |
| Core Tip |
The post-translational modifications of prostaglandin-endoperoxide synthase 2 (PTGS2) appear to be specific signatures of this enzyme in human colorectal cancer (CRC). Glycosylations of PTGS2 that alter the electrophoretic mobility of the protein are mainly observed in the tumor samples but are absent in the non-tumor samples obtained from these patients. These modifications not only may play a pathophysiological role in the progression of CRC but also may provide new biomarkers to develop specific therapeutic interventions. |
| Publish Date |
2018-12-27 08:56 |
| Citation |
Jaén RI, Prieto P, Casado M, Martín-Sanz P, Boscá L. Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer: An update. World J Gastroenterol 2018; 24(48): 5454-5461 |
| URL |
https://www.wjgnet.com/1007-9327/full/v24/i48/5454.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v24.i48.5454 |
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