| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Nomograms for predicting pathological response to neoadjuvant treatments in patients with rectal cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Dong-Lin Ren, Juan Li, Hui-Chuan Yu, Shao-Yong Peng, Wei-Da Lin, Xiao-Lin Wang, Roshan Ara Ghoorun and Yan-Xin Luo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Basic Research Program of China (973 Program) |
2015CB554001 |
| National Natural Science Foundation of China |
81472257 81502022 |
| Natural Science Fund for Distinguished Young Scholars of Guangdong Province |
2016A030306002 |
| Tip-top Scientific and Technical Innovative Youth Talents of Guangdong special support program |
2015TQ01R454 |
| Natural Science Foundation of Guangdong Province |
2016A030310222 2017A030313580 |
| Science and Technology Program of Guangzhou |
201506010099 2014Y2-00160 |
| Fundamental Research Funds for the Central Universities (Sun Yat-sen University) |
2015ykzd10 16ykpy35 17ykpy67 |
| National Key Clinical Discipline |
|
|
| Corresponding Author |
Yan-Xin Luo, MD, PhD, Associate Professor, Chief Doctor, Surgical Oncologist, Department of Colon and Rectum Surgery, Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, 26 Yuancun Erheng Road, Tianhe District, Guangzhou 510655, Guangdong Province, China. luoyx25@mail.sysu.edu.cn |
| Key Words |
Neoadjuvant therapy; Locally advanced rectal cancer; Nomogram; Prediction of pathological response; Complete pathological response; Good downstaging |
| Core Tip |
In this study, we established accurate nomograms for predicting the pathological response (PR) to preoperative neoadjuvant therapy (NT) regimens based on pretreatment parameters for locally advanced rectal cancer (LARC) patients. Logistic regression and nomograms were developed to predict the probability of complete pathological response and good downstaging, respectively, for all patients and for subgroups based on NT regimens. In conclusion, nomograms have been established for predicting the PR to different NT regimens for LARC patients; and these nomograms can be used to facilitate developing individualized treatments. |
| Publish Date |
2019-01-07 10:39 |
| Citation |
Ren DL, Li J, Yu HC, Peng SY, Lin WD, Wang XL, Ghoorun RA, Luo YX. Nomograms for predicting pathological response to neoadjuvant treatments in patients with rectal cancer. World J Gastroenterol 2019; 25(1): 118-137 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i1/118.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i1.118 |
