| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Investigational growth factors utilized in animal models of spinal fusion: Systematic review
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ethan Cottrill, A. Karim Ahmed, Noah Lessing, Zachary Pennington, Wataru Ishida, Alexander Perdomo-Pantoja, Sheng-fu Larry Lo, Elizabeth Howell, Christina Holmes, C. Rory Goodwin, Nicholas Theodore, Daniel Sciubba and Timothy Witham |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ethan Cottrill, MSc, Research Scientist, Department of Neurosurgery, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, United States. ecottri1@jhmi.edu |
| Key Words |
Spinal fusion; Growth factor; Pseudoarthrosis; Systematic review |
| Core Tip |
This is the first study to systematically review all the published investigational growth factors utilized in preclinical animal models of spinal fusion. Among the identified growth factors, calcitonin, GDF-5, NELL-1, and P-15 resulted in fusion rates of 100% in some studies. In addition, six growth factors - AB204, angiopoietin 1, GDF-5, insulin, NELL-1, and peptide B2A - resulted in significantly enhanced fusion rates compared to autologous iliac crest bone graft, BMP-2, or other internal controls in some cases. Directly comparing the fusion efficacy and safety of these growth factors may inform the development of clinically translatable materials for spinal fusion. |
| Publish Date |
2019-04-18 10:30 |
| Citation |
Cottrill E, Ahmed AK, Lessing N, Pennington Z, Ishida W, Perdomo-Pantoja A, Lo SF, Howell E, Holmes C, Goodwin CR, Theodore N, Sciubba DM, Witham TF. Investigational growth factors utilized in animal models of spinal fusion: Systematic review. World J Orthop 2019; 10(4): 176-191 |
| URL |
https://www.wjgnet.com/2218-5836/full/v10/i4/176.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v10.i4.176 |
