Publication Name	World Journal of Gastroenterology
Manuscript ID	42953
Country	China

Received	2018-10-19 06:50
Peer-Review Started	2018-10-19 08:56
To Make the First Decision	2018-11-22 06:23
Return for Revision	2018-11-22 07:14
Revised	2018-11-27 05:14
Second Decision	2018-11-30 09:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-12-01 03:56
Articles in Press	2018-12-01 03:56
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-12-05 13:28
Typeset the Manuscript	2018-12-20 08:29
Publish the Manuscript Online	2018-12-21 10:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatitis C: From inflammatory pathogenesis to anti-inflammatory/hepatoprotective therapy
Manuscript Source	Unsolicited Manuscript
All Author List	Hu Li, Meng-Hao Huang, JD Jiang and Zong-Gen Peng
ORCID	Author(s) ORCID Number Hu Li http://orcid.org/0000-0002-7609-9399 Meng-Hao Huang http://orcid.org/0000-0002-2389-8680 JD Jiang http://orcid.org/0000-0002-1138-2943 Zong-Gen Peng http://orcid.org/0000-0001-7662-6892
Funding Agency and Grant Number	Funding Agency Grant Number CAMS Innovation Fund for Medical Sciences 2017-I2M-3-012 National Natural Science Foundation, China 81773788 National Natural Science Foundation, China 81621064 Ministry of Science and Technology, China 2018ZX09711001-003-010
Corresponding Author	Zong-Gen Peng, PhD, Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Tiantan Xili, Beijing 100050, China. pengzonggen@imb.pumc.edu.cn
Key Words	Hepatitis C virus infection; Liver disease; Inflammatory pathogenesis; Anti-inflammatory and hepatoprotective therapy
Core Tip	Inflammatory responses triggered by hepatitis C virus (HCV) infection lead to severe progressive liver diseases. Some inflammatory cytokines and chemokines may serve as biomarkers for the disease progression and therapeutic effect in chronic hepatitis C (CHC) patients. The inflammatory pathogenesis in HCV-infected patients is complicated, including classic pathogen pattern recognition, inflammasome activation, intrahepatic inflammatory cascade response, and oxidative and endoplasmic reticulum stress. Direct-acting antivirals (DAAs) are not sufficient to block the uncontrolled inflammation and disease progression in severe CHC patients. Therefore, coupling with anti-inflammatory/hepatoprotective agents with anti-HCV effects is a promising therapeutic regimen for advanced HCV-infected patients during or after treatment with DAAs.
Publish Date	2018-12-21 10:07
Citation	Li H, Huang MH, Jiang JD, Peng ZG. Hepatitis C: From inflammatory pathogenesis to anti-inflammatory/hepatoprotective therapy. World J Gastroenterol 2018; 24(47): 5297-5311
URL	https://www.wjgnet.com/1007-9327/full/v24/i47/5297.htm
DOI	https://dx.doi.org/10.3748/wjg.v24.i47.5297

Full Article (PDF)	WJG-24-5297.pdf
Full Article (Word)	WJG-24-5297.docx
Manuscript File	42953-Review.docx
Answering Reviewers	42953-Answering reviewers.pdf
Audio Core Tip	42953-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	42953-Conflict-of-interest statement.pdf
Copyright License Agreement	42953-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	42953-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	42953-Language certificate.pdf
Peer-review Report	42953-Peer-review(s).pdf
Scientific Misconduct Check	42953-Scientific misconduct check.pdf
Scientific Editor Work List	42953-Scientific editor work list.pdf