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Articles Published Processes
12/21/2018 10:07:19 AM | Browse: 1269 | Download: 2231
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Received |
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2018-10-19 06:50 |
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Peer-Review Started |
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2018-10-19 08:56 |
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First Decision by Editorial Office Director |
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2018-11-22 04:34 |
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Return for Revision |
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2018-11-22 07:14 |
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Revised |
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2018-11-27 05:14 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2018-11-30 09:22 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2018-12-01 03:56 |
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Articles in Press |
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2018-12-01 03:56 |
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Edit the Manuscript by Language Editor |
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2018-12-05 13:28 |
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Typeset the Manuscript |
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2018-12-20 08:29 |
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Publish the Manuscript Online |
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2018-12-21 10:07 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Hepatitis C: From inflammatory pathogenesis to anti-inflammatory/hepatoprotective therapy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hu Li, Meng-Hao Huang, JD Jiang and Zong-Gen Peng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| CAMS Innovation Fund for Medical Sciences |
2017-I2M-3-012 |
| National Natural Science Foundation, China |
81773788 |
| National Natural Science Foundation, China |
81621064 |
| Ministry of Science and Technology, China |
2018ZX09711001-003-010 |
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| Corresponding Author |
Zong-Gen Peng, PhD, Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Tiantan Xili, Beijing 100050, China. pengzonggen@imb.pumc.edu.cn |
| Key Words |
Hepatitis C virus infection; Liver disease; Inflammatory pathogenesis; Anti-inflammatory and hepatoprotective therapy |
| Core Tip |
Inflammatory responses triggered by hepatitis C virus (HCV) infection lead to severe progressive liver diseases. Some inflammatory cytokines and chemokines may serve as biomarkers for the disease progression and therapeutic effect in chronic hepatitis C (CHC) patients. The inflammatory pathogenesis in HCV-infected patients is complicated, including classic pathogen pattern recognition, inflammasome activation, intrahepatic inflammatory cascade response, and oxidative and endoplasmic reticulum stress. Direct-acting antivirals (DAAs) are not sufficient to block the uncontrolled inflammation and disease progression in severe CHC patients. Therefore, coupling with anti-inflammatory/hepatoprotective agents with anti-HCV effects is a promising therapeutic regimen for advanced HCV-infected patients during or after treatment with DAAs. |
| Publish Date |
2018-12-21 10:07 |
| Citation |
Li H, Huang MH, Jiang JD, Peng ZG. Hepatitis C: From inflammatory pathogenesis to anti-inflammatory/hepatoprotective therapy. World J Gastroenterol 2018; 24(47): 5297-5311 |
| URL |
https://www.wjgnet.com/1007-9327/full/v24/i47/5297.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v24.i47.5297 |
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