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Articles Published Processes
3/15/2019 6:26:39 AM | Browse: 863 | Download: 1235
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Received |
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2018-10-26 03:26 |
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Peer-Review Started |
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2018-10-26 07:08 |
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To Make the First Decision |
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2018-11-16 02:25 |
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Return for Revision |
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2018-11-28 01:59 |
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Revised |
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2019-01-03 08:20 |
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Second Decision |
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2019-01-08 13:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-01-09 02:40 |
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Articles in Press |
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2019-01-09 02:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-03-14 06:27 |
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Publish the Manuscript Online |
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2019-03-15 06:26 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Human colorectal cancer cells frequently express IgG and display unique Ig repertoire
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Han Geng, Chun-Xiang Ye, Yan Huang, Hong-Peng Jiang, Ying-Jiang Ye, Shan Wang, Yuan Zhou, Zhan-Long Shen and Xiao-Yan Qiu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key support projects of the National Natural Science Foundation's major research program |
91642206 |
| Major international cooperation projects of the National Natural Science Foundation |
81320108020 |
| Beijing Natural Science Foundation |
7182171 |
| Research institute fund of NHC Key Laboratory of Medical Immunology, Peking University |
BMU2018JDJS010 |
| Non-profit central research institute fund of Chinese Academy of Medical Sciences |
2018PT31039 |
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| Corresponding Author |
Xiao-Yan Qiu, MD, PhD, Doctor, Doctor, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Xueyuan Road, Beijing 100191, China. qiuxy@bjmu.edu.cn |
| Key Words |
Immunoglobulin repertoire; Sequencing; Colorectal cancer; VDJ pattern; VJ pattern |
| Core Tip |
It has been found that colon cancer cells can express immunoglobulin (Ig); however, the expression profile and features of the Ig repertoire in colon cancer cells remain unclear. Here, we first sorted colon cancer cells and normal cells from 7 patients with colon cancer. Using the Ig repertoire sequencing, we analyzed the features of the Ig heavy chain (IgH) repertoire in these cells. We found that Ig in colon cancer cells had a significant tendency to choose IgG compared to the other classes of IgH, and showed unique VHDJH patterns and somatic hypermutation hotspots, which might be potential targets for immune therapy for colon cancer. |
| Publish Date |
2019-03-15 06:26 |
| Citation |
Geng ZH, Ye CX, Huang Y, Jiang HP, Ye YJ, Wang S, Zhou Y, Shen ZL, Qiu XY. Human colorectal cancer cells frequently express IgG and display unique Ig repertoire. World Journal of Gastrointestinal Oncology 2019; 11(3): 195-207 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i3/195.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i3.195 |
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