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1/29/2019 2:00:23 AM | Browse: 317 | Download: 271
Publication Name World Journal of Clinical Cases
Manuscript ID 43148
Country/Territory United Kingdom
2018-10-30 10:26
Peer-Review Started
2018-10-31 02:28
To Make the First Decision
2018-11-28 00:30
Return for Revision
2018-12-03 06:54
2018-12-08 15:04
Second Decision
2018-12-12 08:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-12 19:43
Articles in Press
2018-12-12 19:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-01-28 04:45
Publish the Manuscript Online
2019-01-29 02:00
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Observational Study
Article Title Incidence, risk factors, and outcome of BK polyomavirus infection after kidney transplantation
Manuscript Source Invited Manuscript
All Author List Evaldo Favi, Carmelo Puliatti, Rajesh Sivaprakasam, Mariano Ferraresso, Federico Ambrogi, Serena Delbue, Federico Gervasi, Ilaria Salzillo, Nicholas Raison and Roberto Cacciola
Author(s) ORCID Number
Evaldo Favi http://orcid.org/0000-0001-6465-428X
Carmelo Puliatti http://orcid.org/0000-0001-7398-2648
Rajesh Sivaprakasam http://orcid.org/0000-0002-6145-4642
Mariano Ferraresso http://orcid.org/0000-0003-3410-9090
Federico Ambrogi http://orcid.org/0000-0001-9358-011X
Serena Delbue http://orcid.org/0000-0002-3199-9369
Federico Gervasi http://orcid.org/0000-0003-4539-5010
Ilaria Salzillo http://orcid.org/0000-0001-7560-7614
Nicholas Raison http://orcid.org/0000-0003-0496-4985
Roberto Cacciola http://orcid.org/0000-0001-8363-1358
Funding Agency and Grant Number
Corresponding author Evaldo Favi, MD, PhD, Senior Lecturer, Surgeon, Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza n.28, Milan 20122, Italy. evaldofavi@gmail.com
Keywords Polyomavirus; BK virus; Kidney transplantation; Outcome; Risk factors; Immunosuppression; Human leukocyte antigen; Rejection; Cytomegalovirus; Ethnicity
Core Tip Polyomavirus-associated nephropathy is a leading cause of kidney transplant failure. A systematic screening and treatment protocol in line with current international guideline was evaluated. Our results showed that despite early diagnosis and prompt intervention, graft-related outcomes for patients with BK-virus infection remain substantially inferior to control. We confirmed that initial viral load ≥ 10000 copies/mL is highly predictive of nephropathy. New putative risk factors for BK-viremia and nephropathy were also identified. Properly designed large multi-centre studies are warranted to further investigate individual susceptibility to BK-virus infection and validate alternative antiviral therapies.
Publish Date 2019-01-29 02:00
Citation Favi E, Puliatti C, Sivaprakasam R, Ferraresso M, Ambrogi F, Delbue S, Gervasi F, Salzillo I, Raison N, Cacciola R. Incidence, risk factors, and outcome of BK polyomavirus infection after kidney transplantation. World J Clin Cases 2019; 7(3): 270-290
Url https://www.wjgnet.com/2307-8960/full/v7/i3/270.htm
DOI https://dx.doi.org/10.12998/wjcc.v7.i3.270
Full Article (PDF) WJCC-7-270.pdf
Full Article (Word) WJCC-7-270.docx
Manuscript File 43148-Review.docx
Answering Reviewers 43148-Answering reviewers.pdf
Audio Core Tip 43148-Audio core tip.mp3
Biostatistics Review Certificate 43148-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 43148-Conflict-of-interest statement.pdf
Copyright License Agreement 43148-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 43148-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 43148-Institutional review board statement.pdf
Peer-review Report 43148-Peer-review(s).pdf
Scientific Misconduct Check 43148-Scientific misconduct check.pdf
Scientific Editor Work List 43148-Scientific editor work list.pdf