| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Marco Biolato, Fiorella Manca, Giuseppe Marrone, Consuelo Cefalo, Simona Racco, Giacinto A.D. Miggiano, Venanzio Valenza, Antonio Gasbarrini, Luca Miele and Antonio Grieco |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| This work was supported by a grant by the Italian Ministry of Education, University and Research (MIUR), scientific research programmes of relevant national interest (PRIN) year 2010-2011 |
2010C4JJWB |
|
| Corresponding Author |
Marco Biolato, MD, PhD, Staff Physician, Liver Transplant Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, Rome 00168, Italy. marco.biolato@policlinicogemelli.it |
| Key Words |
Liver steatosis; Gut-liver axis; Nutrition; Personalized medicine; Visceral obesity |
| Core Tip |
Diet, as well as intestinal microbiota, is a key regulator of intestinal permeability, the alteration of which is central in the derangement of the gut-liver axis. In patients with non-alcoholic fatty liver disease (NAFLD), intestinal permeability is increased, promoting translocation of bacteria-derived products into the portal circulation and increasing hepatic exposure to injurious substances that stimulate hepatic inflammation and fibrosis in animal models, high-fat diet or high-fructose intake has been associated with increased gut permeability. The aim of this study was to detect diet-induced modification of intestinal permeability in non-diabetic patients with NAFLD undergoing a Mediterranean diet or a low-fat diet. |
| Publish Date |
2019-01-26 11:40 |
| Citation |
Biolato M, Manca F, Marrone G, Cefalo C, Racco S, Miggiano GA, Valenza V, Gasbarrini A, Miele L, Grieco A. Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease. World J Gastroenterol 2019; 25(4): 509-520 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i4/509.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i4.509 |
