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Articles Published Processes
1/16/2019 7:45:37 AM | Browse: 988 | Download: 1377
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Received |
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2018-11-03 09:09 |
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Peer-Review Started |
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2018-11-05 11:08 |
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To Make the First Decision |
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2018-11-29 07:52 |
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Return for Revision |
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2018-12-06 08:35 |
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Revised |
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2018-12-11 14:46 |
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Second Decision |
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2019-01-03 11:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-01-06 02:17 |
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Articles in Press |
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2019-01-06 02:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-01-15 05:59 |
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Publish the Manuscript Online |
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2019-01-16 07:45 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Minireviews |
| Article Title |
Machine perfusion of the liver: Which is the best technique to mitigate ischaemia-reperfusion injury?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yuri L Boteon and Simon C Afford |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Simon C Afford, FRCPA, PhD, Reader (Associate Professor), Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. s.c.afford@bham.ac.uk |
| Key Words |
Machine perfusion of the liver; Ischaemia-reperfusion injury; Liver transplantation; Organ preservation; Organ reconditioning |
| Core Tip |
Hepatic ischaemia–reperfusion injury (IRI) is the main culprit of post-transplantation graft dysfunction and ischaemic-type biliary lesions. Despite the increased demand, extended-criteria donor livers are more vulnerable to IRI, thereby presenting inferior postoperative outcomes. Hence, the mitigation of IRI should drive the setting of a new benchmark for extended-criteria donor organ preservation. Machine perfusion of the liver has the potential to mitigate IRI via a shortening of the ischaemic period of the livers or the reconditioning of their bioenergetic status. Interventions to further alleviate IRI, such as pharmacological or nonpharmacological metabolic modulation of donor organs, may amplify this effect. |
| Publish Date |
2019-01-16 07:45 |
| Citation |
Boteon YL, Afford SC. Machine perfusion of the liver: Which is the best technique to mitigate ischaemia-reperfusion injury? World J Transplant 2019; 9(1): 14-20 |
| URL |
https://www.wjgnet.com/2220-3230/full/v9/i1/14.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v9.i1.14 |
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