BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
3/20/2019 5:32:10 AM | Browse: 923 | Download: 1113
Publication Name World Journal of Gastroenterology
Manuscript ID 43477
Country/Territory South Korea
Received
2018-11-20 01:20
Peer-Review Started
2018-11-20 03:06
To Make the First Decision
2019-01-31 01:29
Return for Revision
2019-01-31 01:32
Revised
2019-02-19 12:04
Second Decision
2019-02-22 09:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-02-23 05:22
Articles in Press
2019-02-23 05:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-19 06:48
Publish the Manuscript Online
2019-03-20 05:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Clinical assessment and identification of immuno-oncology markers concerning the 19-gene based risk classifier in stage IV colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Jong Lyul Lee, Seon Ae Roh, Chan Wook Kim, Yi Hong Kwon, Ye Jin Ha, Seon-Kyu Kim, Seon-Young Kim, Dong-Hyung Cho, Yong Sung Kim and Jin Cheon Kim
ORCID
Author(s) ORCID Number
Jong Lyul Lee http://orcid.org/0000-0002-5878-8000
Seon Ae Roh http://orcid.org/0000-0002-6371-4778
Chan Wook Kim http://orcid.org/0000-0002-2382-0939
Yi Hong Kwon http://orcid.org/0000-0001-8422-4324
Ye Jin Ha http://orcid.org/0000-0003-2001-7435
Seon-Kyu Kim http://orcid.org/0000-0002-4176-5187
Seon-Young Kim http://orcid.org/0000-0002-1030-7730
Dong-Hyung Cho http://orcid.org/0000-0002-8859-0310
Yong Sung Kim http://orcid.org/0000-0001-7113-272X
Jin Cheon Kim http://orcid.org/0000-0003-4823-8619
Funding Agency and Grant Number
Funding Agency Grant Number
the Korea Research Foundation 2016R1E1A1A02919844
the Asan Institute for Life Sciences, Asan Medical Center 2016-710
the Korea Research Foundation 2017R1A2B1009062
Corresponding Author Jin Cheon Kim, MD, PhD, Doctor, Professor, Surgeon, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. jckim@amc.seoul.kr
Key Words Colorectal cancer; Prognosis; Immunotherapy; Signaling lymphocytic activation molecule family, member 7; Triggering receptor expressed on myeloid cells 1
Core Tip The current study showed that in the patients with stage IV colorectal cancer (CRC) and a higher 19-gene based risk classifier score, the target-regimen-specific progression-free survival (PFS) was significantly increased compared with the 5-fluorouracil-regimen-specific PFS. Using another 10 validate set, down-regulation of signaling lymphocytic activation molecule family, member 7 (SLAMF7) and up-regulation of triggering receptor expressed on myeloid cells 1 were identified in primary and metastatic tumors compared with normal tissue. In CRC cells expressing SLAMF7 that were co-cultured with a monocytic cell line, levels of CD68 and CD73 were significantly lower at day 5 of co-culture than at day 0.
Publish Date 2019-03-20 05:32
Citation Lee JL, Roh SA, Kim CW, Kwon YH, Ha YJ, Kim SK, Kim SY, Cho DH, Kim YS, Kim JC. Clinical assessment and identification of immuno-oncology markers concerning the 19-gene based risk classifier in stage IV colorectal cancer. World J Gastroenterol 2019; 25(11): 1341-1354
URL https://www.wjgnet.com/1007-9327/full/v25/i11/1341.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i11.1341
Full Article (PDF) WJG-25-1341.pdf
Full Article (Word) WJG-25-1341.docx
The ARRIVE Guidelines 43477-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 43477-Review.docx
Answering Reviewers 43477-Answering reviewers.pdf
Audio Core Tip 43477-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 43477-Conflict-of-interest statement.pdf
Copyright License Agreement 43477-Copyright license agreement.PDF
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 43477-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 43477-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 43477-Language certificate.pdf
Supplementary Material 43477-Supplementary material.pdf
Peer-review Report 43477-Peer-review(s).pdf
Scientific Misconduct Check 43477-Google-MA RY-2.png
Scientific Misconduct Check 43477-Scientific misconduct check.pdf
Scientific Editor Work List 43477-Scientific editor work list.pdf