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Publication Name World Journal of Biological Chemistry
Manuscript ID 4371
Country/Territory United States
Received
2013-06-28 11:42
Peer-Review Started
2013-06-28 17:48
To Make the First Decision
2013-07-26 18:30
Return for Revision
2013-08-06 09:49
Revised
2013-08-31 02:53
Second Decision
2013-11-04 16:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-11-05 09:03
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-11-26 12:13
Publish the Manuscript Online
2013-12-06 18:20
ISSN 1949-8454 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Minireviews
Article Title Adaptive and maladaptive expression of the mRNA regulatory protein HuR
Manuscript Source Invited Manuscript
All Author List Suman Govindaraju and Beth S Lee
Funding Agency and Grant Number
Corresponding Author Beth S Lee, PhD, Associate Professor, Department of Physiology and Cell Biology, Ohio State University College of Medicine, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, United States. lee.2076@osu.edu
Key Words HuR; RNA binding proteins; Transcription; RNA stability; Translation; Protein stability; Cell stress; MicroRNAs; Cancer
Core Tip HuR is an RNA-binding protein that regulates post-transcriptional processing of thousands of mRNAs, including many that encode proteins that are critical to basic cellular functions. Thus, while loss of HuR can lead to cell death, pathological overexpression of HuR is associated with numerous types of cancer. However, the mechanisms that govern expression of HuR have only begun to be delineated. This review summarizes the current state of knowledge of these mechanisms and how they may contribute to cell survival and pathology.
Publish Date 2013-12-06 18:20
Citation Govindaraju S, Lee BS. Adaptive and maladaptive expression of the mRNA regulatory protein HuR. World J Biol Chem 2013; 4(4): 111-118
URL http://www.wjgnet.com/1949-8454/full/v4/i4/111.htm
DOI http://dx.doi.org/10.4331/wjbc.v4.i4.111
Full Article (PDF) WJBC-4-111.pdf
Manuscript File 4371-Review.docx
Answering Reviewers 4371-Answering reviewers.pdf
Copyright License Agreement 4371-Copyright assignment.pdf
Peer-review Report 4371-Peer reviewer(s).pdf
Scientific Editor Work List 4371-Scientific editor work list.doc