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9/15/2014 5:55:00 PM | Browse: 1107 | Download: 1255
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Received |
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2013-06-28 12:34 |
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Peer-Review Started |
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2013-06-28 19:09 |
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To Make the First Decision |
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2013-07-05 18:33 |
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Return for Revision |
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2013-07-09 13:13 |
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Revised |
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2013-07-13 12:01 |
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Second Decision |
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2013-08-16 19:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2013-08-17 00:15 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2013-09-11 13:46 |
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Publish the Manuscript Online |
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2013-10-31 14:50 |
Category |
Cell Biology |
Manuscript Type |
Review |
Article Title |
MicroRNAs as novel regulators of stem cell fate
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Manuscript Source |
Invited Manuscript |
All Author List |
Eunhyun Choi, Eunmi Choi and Ki-Chul Hwang |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
South Korea Science |
2011-0019243 |
Engineering Foundation |
2011-0019254 |
South Korea Health 21 R and D Project, Ministry of Health and Welfare, South Korea |
A120478 |
Korea Health 21 R and D Project, Ministry of Health and Welfare, South Korea |
A085136 |
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Corresponding Author |
Ki-Chul Hwang, PhD, Severance Biomedical Science Institute, Cardiovascular Research Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, South Korea. kchwang@yuhs.ac |
Key Words |
MicroRNA; Stem cell fate; Differentiation; Self-renewal; Reprogramming; Small molecule |
Core Tip |
Stem cells are important in regenerative medicine applications due to their capacity to self-renew and differentiate into specific cell types. MicroRNAs (miRNAs) are short non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. Recent studies suggest that miRNAs are key molecules in the regulation of stem cell fate decisions; this regulation is manifested as the fine tuning of cell- and tissue-specific gene expression. This review summarizes the current insights into stem cell fate determination by miRNAs and focuses on stem cell self-renewal, differentiation, and reprogramming. Small molecules that control stem cell fate are also highlighted. |
Publish Date |
2013-10-31 14:50 |
Citation |
Choi E, Choi E, Hwang KC. MicroRNAs as novel regulators of stem cell fate. World J Stem Cells 2013; 5(4): 172-187 |
URL |
http://www.wjgnet.com/1948-0210/full/v5/i4/172.htm |
DOI |
http://dx.doi.org/10.4252/wjsc.v5.i4.172 |
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