Publication Name	World Journal of Medical Genetics
Manuscript ID	4391
Country	Singapore

Received	2013-06-28 17:28
Peer-Review Started	2013-06-28 22:39
To Make the First Decision	2013-08-21 18:34
Return for Revision	2013-08-23 10:16
Revised
Second Decision	2013-11-08 08:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-08 10:15
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-29 10:14
Publish the Manuscript Online	2013-12-16 13:25

ISSN	2220-3184 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Toxicology
Manuscript Type	Review
Article Title	Genetic alterations in head and neck squamous cell carcinoma: The next-gen sequencing era
Manuscript Source	Invited Manuscript
All Author List	Thien Khanh Nguyen and N Gopalakrishna Iyer
Funding Agency and Grant Number
Corresponding Author	N Gopalakrishna Iyer, MBBS (Hons) (Singapore), PhD (Cantab), FRCS (Gen), FAMS, Senior Consultant, Head and Neck Surgeon and Director of Research, Department of Surgical Oncology, Principal Investigator, Cancer Therapeutics Research Laboratory, National Cancer Centre, 11 Hospital Dr, Singapore 169610, Singapore. gopaliyer@nccs.com.sg
Key Words	Head and neck squamous cell carcinoma; TP53; Ras/PIK3CA; NOTCH1/p63; HPV/E6/E7/Rb/CDKN2A
Core Tip	Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world with approximately 650000 new cases diagnosed annually. Understanding the molecular pathways that are implicated in the pathogenesis of HNSCC enable clinicians to be able to classify and to prognosticate the disease based on subtypes, such as human papilloma virus (HPV)-positive vs HPV-negative HNSCC. More importantly, patients may be placed on de escalated or more aggressive therapies depend on their tumor subtypes and prognosis. This paper aims to review our current knowledge of the most common genetic alterations in HNSCC.
Publish Date	2013-12-16 13:25
Citation	Nguyen TK, Iyer NG. Genetic alterations in head and neck squamous cell carcinoma: The next-gen sequencing era. World J Med Genet 2013; 3(4): 22-33
URL	http://www.wjgnet.com/2220-3184/full/v3/i4/22.htm
DOI	http://dx.doi.org/10.5496/wjmg.v3.i4.22

Full Article (PDF)	WJMG-3-22.pdf
Full Article (Word)	WJMG-3-22.doc
Manuscript File	4391-Review.docx
Answering Reviewers	4391-Answering reviewers.pdf
Copyright License Agreement	4391-Copyright assignment.pdf
Peer-review Report	4391-Peer review(s).pdf
Scientific Editor Work List	4391-Scientific editor work list.doc