Publication Name	World Journal of Nephrology
Manuscript ID	4443
Country

Received	2013-06-29 20:22
Peer-Review Started	2013-06-29 21:51
First Decision by Editorial Office Director
Return for Revision	2013-07-20 23:07
Revised	2013-08-15 13:01
Publication Fee Transferred
Second Decision by Editor	2013-08-20 12:14
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-08-20 13:50
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-27 12:22
Publish the Manuscript Online	2013-09-05 13:08

ISSN	2220-6124 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Minireviews
Article Title	Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases
Manuscript Source
All Author List	Hong Zhao, Yanting Dong, Xinrui Tian, Thian Kui Tan, Zhuola Liu, Ye Zhao, Yun Zhang, David CH Harris and Guoping Zheng
Funding Agency and Grant Number
Corresponding Author	Guoping Zheng, MD, PhD, Centre for Transplantation and Renal Research, Westmead Millennium Institute, the University of Sydney, City Road, NSW 2145, Sydney, Australia. guoping.zheng@sydney.edu.au
Key Words	Matrix metalloproteinase; Chronic kidney disease; Kidney fibrosis; Epithelial–mesenchymal transition Transforming growth factor-β
Core Tip	Matrix metalloproteinases (MMPs) were previously known to be anti-fibrotic for their ability to degrade and remodel extracellular matrix proteins. Recent studies including our own have shown that MMPs are implicated in initiation and progression of kidney fibrosis. MMP-9 of both tubular and macrophage origins were found to be able to induce epithelial-mesenchymal transition of tubular cells, an important mechanism causing kidney fibrosis. This review, by focus on MMP-9 and epithelial–mesenchymal transition, seeks to provide a comprehensive understanding for the roles of MMPs in kidney fibrosis.
Publish Date	2013-09-05 13:08
Citation	Zhao H, Dong Y, Tian X, Tan TK, Liu Z, Zhao Y, Zhang Y, Harris DC, Zheng G. Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases. World J Nephrol 2013; 2(3): 84-89
URL	http://www.wjgnet.com/2220-6124/full/v2/i3/84.htm
DOI	http://dx.doi.org/10.5527/wjn.v2.i3.84

Full Article (PDF)	WJN-2-84.pdf
Manuscript File	4443-Review.docx
Answering Reviewers	4443-Answering reviewers.pdf
Copyright License Agreement	4443-Copyright assignment.pdf
Peer-review Report	4443-Peer review(s).pdf
Scientific Editor Work List	4443-Scientific editor work list.doc