Publication Name	World Journal of Orthopedics
Manuscript ID	44584
Country	United States

Received	2018-11-16 02:45
Peer-Review Started	2018-11-19 07:10
To Make the First Decision	2018-12-17 07:06
Return for Revision	2018-12-28 07:21
Revised	2019-01-06 19:26
Second Decision	2019-01-22 10:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-01-28 18:56
Articles in Press	2019-01-28 18:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-03-07 08:56
Publish the Manuscript Online	2019-03-08 07:13

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Linkage of microbiota and osteoporosis: A mini literature review
Manuscript Source	Invited Manuscript
All Author List	David Yatsonsky II, Karen Pan, Vithal B Shendge, Jiayong Liu and Nabil A Ebraheim
ORCID	Author(s) ORCID Number David Yatsonsky II http://orcid.org/0000-0002-4173-8322 Karen Pan http://orcid.org/0000-0002-3001-8928 Vithal B Shendge http://orcid.org/0000-0001-7697-2496 Jiayong Liu http://orcid.org/0000-0002-5895-8276 Nabil A Ebraheim http://orcid.org/0000-0002-0950-3689
Funding Agency and Grant Number
Corresponding Author	Jiayong Liu, MD, Assistant Professor, Department of Orthopedic Surgery, University of Toledo Medical Center, 3065 Arlington Avenue, Toledo, OH 43614, United States. jiayong.liu@utoledo.edu
Key Words	Osteoporosis; Microbiota; Linkage; Bone density; Gut microbiota
Core Tip	Assessing patients with osteoporosis (OP), there is a strong correlation between gut microbe dysregulation and decreased bone density. Gut dysbiosis may lead to inflammation, dysregulation of nutrient and calcium transport across the intestine into circulation and systemic inflammation. Therapies to normalize gut microbiota in patients with OP or prevent occurrence of OP to be investigated include: High fiber prebiotic diets to promote growth of normal gut bacteria and short chain fatty acid production, Probiotics to encourage growth of normal gut microbes, and antibiotic treatment followed by fecal matter transplant.
Publish Date	2019-03-08 07:13
Citation	Yatsonsky II D, Pan K, Shendge VB, Liu J, Ebraheim NA. Linkage of microbiota and osteoporosis: A mini literature review. World J Orthop 2019; 10(3): 123-127
URL	https://www.wjgnet.com/2218-5836/full/v10/i3/123.htm
DOI	https://dx.doi.org/10.5312/wjo.v10.i3.123

Full Article (PDF)	WJO-10-123.pdf
Full Article (Word)	WJO-10-123.docx
Manuscript File	44584-Review.docx
Answering Reviewers	44584-Answering reviewers.pdf
Audio Core Tip	44584-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	44584-Conflict-of-interest statement.pdf
Copyright License Agreement	44584-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	44584-Language certificate.pdf
Peer-review Report	44584-Peer-review(s).pdf
Scientific Misconduct Check	44584-Scientific misconduct check.pdf
Scientific Editor Work List	44584-Scientific editor work list.pdf