| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dynamic changes of key metabolites during liver fibrosis in rats by ultra-performance liquid chromatography-mass spectrometry
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jiong Yu, Jian-Qin He, De-Ying Chen, Qiao-Ling Pan, Jin-Feng Yang, Hong-Cui Cao and Lan-Juan Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Stem Cell and Translational Research, the National Key Research and Development Program of China |
2016YFA0101001 |
|
| Corresponding Author |
Lan-Juan Li, MD, PhD, Academic Research, Doctor, Doctor, Professor, Senior Researcher, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. ljli@zju.edu.cn |
| Key Words |
Ultra-performance liquid chromatography-mass spectrometry; Metabonomics; Liver fibrosis; Biomarker; Cervonoyl ethanolamide; β-muricholic acid |
| Core Tip |
Carbon tetrachloride induced model is stable and comparable with viral hepatitis. Dynamic changes reveal metabolic changes occur during the progression of fibrosis. We investigated the association of liver fibrosis with 21 metabolites, two of them, cervonoyl ethanolamide and β-muricholic acid, differed significantly in the fibrosis model rats compared to controls (P < 0.05) and showed prognostic value for fibrosis. The receiver operating characteristic results showed both two metabolites had excellent diagnostic value and could be used in clinical diagnosis in the future. |
| Publish Date |
2019-02-27 04:11 |
| Citation |
Yu J, He JQ, Chen DY, Pan QL, Yang JF, Cao HC, Li LJ. Dynamic changes of key metabolites during liver fibrosis in rats. World J Gastroenterol 2019; 25(8): 941-954 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i8/941.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i8.941 |
