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Articles Published Processes
4/26/2019 3:39:24 AM | Browse: 1024 | Download: 1376
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Received |
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2018-11-28 01:22 |
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Peer-Review Started |
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2018-11-28 05:50 |
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To Make the First Decision |
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2019-01-30 03:27 |
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Return for Revision |
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2019-02-12 07:25 |
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Revised |
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2019-02-21 14:45 |
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Second Decision |
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2019-03-22 08:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-25 04:54 |
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Articles in Press |
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2019-03-25 04:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-04-24 05:55 |
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Publish the Manuscript Online |
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2019-04-26 03:39 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
MicroRNAs contribute to ATP-binding cassette transporter- and autophagy-mediated chemoresistance in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Maria V Espelt, Maria L Bacigalupo, Pablo Carabias and Maria F Troncoso |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Maria F Troncoso, PhD, Academic Research, Research Assistant Professor, Facultad de Farmacia y Bioquímica, Instituto de Química y Fisicoquímica Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Junín 956, Buenos Aires C1113AAD, Argentina. ma.f.troncoso@gmail.com |
| Key Words |
Hepatocellular carcinoma; Chemoresistance; ABC transporter; Autophagy; miRNA |
| Core Tip |
The main obstacle during treatment of hepatocellular carcinoma (HCC) is resistance to chemotherapy. We analyzed microRNAs (miRNAs) impact on HCC chemoresistance. Certain miRNAs target ABC transporter genes. As most of these miRNAs are downregulated in HCC, transporter levels increase and intracellular drug accumulation decrease, turning cells less sensitive to death. Others miRNAs target autophagy-related gene expression, inhibiting autophagy and acting as tumor suppressors. Nevertheless, due to its downregulation in HCC, these miRNAs do not inhibit autophagy or tumor growth and, resistance is favored. ABC transporter and/or autophagy-related gene expression modulated by miRNAs affect HCC cell survival under chemotherapy. |
| Publish Date |
2019-04-26 03:39 |
| Citation |
Espelt MV, Bacigalupo ML, Carabias P, Troncoso MF. MicroRNAs contribute to ATP-binding cassette transporter- and autophagy-mediated chemoresistance in hepatocellular carcinoma. World J Hepatol 2019; 11(4): 344-358 |
| URL |
https://www.wjgnet.com/1948-5182/full/v11/i4/344.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v11.i4.344 |
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