| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Integrated network analysis of transcriptomic and protein–protein interaction data in the taurine-treated hepatic stellate cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xing-Qiu Liang, Jian Liang, Xiao-Fang Zhao, Xin-Yuan Wang and Xin Deng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation Program of China |
81360595 |
| National Natural Science Foundation Program of China |
81360532 |
| Guangxi Natural Science Foundation Program |
NO. KJT13066 |
| the Bagui Scholars Foundation Program of Guangxi |
|
| the Special-term Experts Foundation Program of Guangxi |
|
| the project of Guangxi young teacher fundamental ability promotion |
2017KY0298 |
|
| Corresponding Author |
Xin Deng, MD, PhD, Professor, School of Basic Science, Guangxi University of Chinese Medicine, Xianhu avenue 13, Nanning 530200, Guangxi Zhuang Autonomous Region, China. 260446391@qq.com |
| Key Words |
Taurine; hepatic stellate cells; Differentially expressed genes; Liver fibrogenesis; Transcriptomic; Protein–protein interaction network |
| Core Tip |
We report our first results derived from integrating transcriptomic and protein–protein interaction data by methods of microarrays, bioinformatics, protein-protein interaction network, and sub-modules, which allowed us to identify the key targets genes involved in taurine promoting hepatic stellate cells (HSCs) apoptosis. This study demonstrates for the first time that taurine promotes the apoptosis of HSCs via upregulating TGFB1 and then activating p38 MAPK-JNK-Caspase9/8/3 pathway. MMP2, MMP9, MMP21, TIMP3, KLF10, CX3CR1, TGFB1, VEGFB, and EGF may be the important targets of taurine in HSCs. |
| Publish Date |
2019-03-07 03:51 |
| Citation |
Liang XQ, Liang J, Zhao XF, Wang XY, Deng X. Integrated network analysis of transcriptomic and protein-protein interaction data in taurine-treated hepatic stellate cells. World J Gastroenterol 2019; 25(9): 1067-1079 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i9/1067.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i9.1067 |
