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Articles Published Processes
1/26/2019 11:40:14 AM | Browse: 1359 | Download: 1544
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Received |
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2018-11-30 01:33 |
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Peer-Review Started |
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2018-11-30 05:48 |
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To Make the First Decision |
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2019-01-11 06:32 |
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Return for Revision |
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2019-01-11 07:48 |
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Revised |
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2019-01-15 17:06 |
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Second Decision |
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2019-01-18 11:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-01-18 23:11 |
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Articles in Press |
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2019-01-18 23:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-01-25 02:12 |
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Publish the Manuscript Online |
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2019-01-26 11:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Murali Ganesan, Larisa Y Poluektova, Kusum K Kharbanda and Natalia A Osna |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH-NIAAA |
K01AA026864 |
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| Corresponding Author |
Murali Ganesan, PhD, Instructor, Research Service (151), Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Ave, Omaha, NE 68105, United States. murali.ganesan@unmc.edu |
| Key Words |
Human immunodeficiency virus; Hepatitis C virus; Hepatitis B virus; Fibrosis; Stiffness; Treatment |
| Core Tip |
In this review, we summarized the literature and our recent findings on liver damage associated with co-infection with human immunodeficiency virus (HIV) and hepatotropic viruses [hepatitis C virus (HCV), hepatitis B virus (HBV)]. The combination of HIV with HCV or HBV causes progressive liver injury and chronic liver inflammation ultimately leading to end-stage liver disease, such as cirrhosis and hepatocellular carcinoma. These outcomes are related to many events including apoptosis-mediated cross-talk between liver parenchymal and non-parenchymal cells, accumulation of inflammatory cells in the liver, microbial translocation and impaired immune responses. The treatment of these co-infections requires the combination of direct acting antiviral (DAA) and antiretroviral therapy (ART) for HCV+HIV and comparatively high doses of DAA for HBV, which should be controlled for drug-drug interactions to avoid hepatotoxicity. |
| Publish Date |
2019-01-26 11:40 |
| Citation |
Ganesan M, Poluektova LY, Kharbanda KK, Osna NA. Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression. World J Gastroenterol 2019; 25(4): 398-410 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i4/398.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i4.398 |
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