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Articles Published Processes
4/24/2019 3:39:52 PM | Browse: 739 | Download: 1447
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Received |
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2018-12-02 06:04 |
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Peer-Review Started |
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2018-12-03 00:42 |
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To Make the First Decision |
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2019-01-02 01:12 |
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Return for Revision |
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2019-01-08 06:30 |
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Revised |
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2019-01-25 09:49 |
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Second Decision |
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2019-02-26 08:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-02-28 07:34 |
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Articles in Press |
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2019-02-28 07:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-04-24 08:33 |
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Publish the Manuscript Online |
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2019-04-24 15:39 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinicohistopathological implications of phosphoserine 9 glycogen synthase kinase-3β/ β-catenin in urinary bladder cancer patients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Niharika Maurya, Rinni Singh, Apul Goel, Atin Singhai, Uday Pratap Singh, Vinita Agrawal and Minal Garg |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Department of Science and Technology, Govt. of India |
SR/SO/HS-0113/2010 |
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| Corresponding Author |
Minal Garg, MSc, PhD, Assistant Professor, Department of Biochemistry, Lucknow University, Lucknow 226007, India. minal14@yahoo.com |
| Key Words |
Pathobiology; Target genes; Tumor stage and grade; Wnt/β–catenin signal cascade; Urothelial carcinoma of bladder |
| Core Tip |
Aberrant co-expression of phosphorylated form of glycogen synthase kinase-3β (pS9GSK-3β) and β–catenin proteins and their association with tumor stage, tumor type, smoking/tobacco chewing status and shorter overall survival probabilities of urinary bladder cancer patients validate them as potential markers of diagnostic/prognostic significance in disease pathogenesis. Observed histopathological association of nuclear Cyclin D1 identifies it as a marker of potential relevance in tumors with altered pS9GSK-3β/β-catenin proteins. These results rule out the possible post translational activation of target genes examined, by pS9GSK-3β/β-catenin/T-cell factor/lymphoid enhancer factor transcriptional complex in bladder tumorigenesis. |
| Publish Date |
2019-04-24 15:39 |
| Citation |
Maurya N, Singh R, Goel A, Singhai A, Singh UP, Agrawal V, Garg M. Clinicohistopathological implications of phosphoserine 9 glycogen synthase kinase-3β/ β-catenin in urinary bladder cancer patients. World J Clin Oncol 2019; 10(4): 166-182 |
| URL |
https://www.wjgnet.com/2218-4333/full/v10/i4/166.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v10.i4.166 |
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