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Articles Published Processes
3/14/2019 12:55:48 AM | Browse: 832 | Download: 1494
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Received |
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2018-12-11 01:56 |
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Peer-Review Started |
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2018-12-11 02:27 |
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To Make the First Decision |
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2018-12-29 01:04 |
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Return for Revision |
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2018-12-29 02:13 |
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Revised |
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2019-01-27 03:19 |
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Second Decision |
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2019-01-28 09:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-01-28 19:38 |
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Articles in Press |
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2019-01-28 19:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-01-31 09:30 |
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Typeset the Manuscript |
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2019-03-13 00:40 |
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Publish the Manuscript Online |
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2019-03-14 00:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
MicroRNA-596 acts as a tumor suppressor in gastric cancer and is upregulated by promotor demethylation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhen Zhang and Dong-Qiu Dai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 30572162 |
| Natural Science Foundation of Liaoning Province |
No. 201602817 |
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| Corresponding Author |
Dong-Qiu Dai, PhD, Chief Doctor, Professor, Surgical Oncologist, Department of Gastrointestinal Surgery, the Fourth Affiliated Hospital of China Medical University, 4 Chongshan Road, Shenyang 110032, Liaoning Province, China. daidq63@163.com |
| Key Words |
Gastric cancer; MicroRNA-596; Methylation; Peroxiredoxin 1 |
| Core Tip |
In the present study, we have investigated a suppressive role of microRNA-596 (miR-596) in gastric cancer (GC). We reported that miR-596 is downregulated in human specimens of GC and GC cell lines, and that overexpression of miR-596 significantly reduces GC cell proliferation. Moreover, the downregulation of miR-596 in GC cell lines was associated with an increase of miR-596 promoter methylation. We also established that miR-596 controls the expression of peroxiredoxin 1, which has never been reported before, suggesting that this interaction could play an important role in GC progression. Overall, this study has an impact in understanding the role of miRNAs in cancer progression. |
| Publish Date |
2019-03-14 00:55 |
| Citation |
Zhang Z, Dai DQ. MicroRNA-596 acts as a tumor suppressor in gastric cancer and is upregulated by promotor demethylation. World J Gastroenterol 2019; 25(10): 1224-1237 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i10/1224.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i10.1224 |
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