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Articles Published Processes
2/27/2019 4:11:15 AM | Browse: 957 | Download: 1665
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Received |
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2018-12-17 02:05 |
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Peer-Review Started |
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2018-12-17 08:07 |
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To Make the First Decision |
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2019-01-18 07:48 |
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Return for Revision |
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2019-01-18 09:35 |
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Revised |
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2019-01-25 04:29 |
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Second Decision |
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2019-01-28 09:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-01-28 19:34 |
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Articles in Press |
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2019-01-28 19:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-02-05 21:23 |
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Typeset the Manuscript |
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2019-02-26 07:42 |
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Publish the Manuscript Online |
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2019-02-27 04:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Procyanidin B2 protects against diet-induced obesity and non-alcoholic fatty liver disease via the modulation of the gut microbiota in rabbits
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ya-Wei Xing, Guang-Tao Lei, Qing-Hua Wu, Yu Jiang and Man-Xiang Huang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Major projects of Science and Technology in Jiangxi |
20161ACG70012 |
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| Corresponding Author |
Guang-Tao Lei, MD, Chief Doctor, Department of Cardiovascular medicine, the Second Affiliated Hospital of Nanchang University, 1st Minde Road, Nanchang 330006, Jiangxi Province, China. lgtmhu@163.com |
| Key Words |
Procyanidin; Rabbit; Non-alcoholic fatty liver disease; Gut microbiota; 16S rRNA |
| Core Tip |
Procyanidin are widely recognized for their excellent antioxidant properties and fewer side effects than drugs. In the past, the mechanism of procyanidin to improve insulin resistance mainly focused on the antioxidant effect. The effect of procyanidin on non-alcoholic fatty liver disease (NAFLD) is not clear. We found that procyaindin can reduce fatty liver by remodeling intestinal flora, decreasing endotoxemia, and down-regulating fatty acid synthesis genes. Our results would open a new chapter in the mechanism of action of plant compounds and suggest a safer method for the treatment of NAFLD. |
| Publish Date |
2019-02-27 04:11 |
| Citation |
Xing YW, Lei GT, Wu QH, Jiang Y, Huang MX. Procyanidin B2 protects against diet-induced obesity and non-alcoholic fatty liver disease via the modulation of the gut microbiota in rabbits. World J Gastroenterol 2019; 25(8): 955-966 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i8/955.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i8.955 |
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