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Articles Published Processes
4/15/2019 10:50:47 AM | Browse: 943 | Download: 1907
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Received |
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2018-12-26 01:42 |
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Peer-Review Started |
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2018-12-26 02:09 |
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To Make the First Decision |
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2019-01-19 04:36 |
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Return for Revision |
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2019-01-23 03:24 |
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Revised |
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2019-02-13 08:27 |
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Second Decision |
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2019-03-15 08:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-16 15:24 |
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Articles in Press |
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2019-03-16 15:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-04-15 02:29 |
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Publish the Manuscript Online |
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2019-04-15 10:50 |
| ISSN |
1948-5204 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Significance of HER2 protein expression and HER2 gene amplification in colorectal adenocarcinomas
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Yu Wang, Zhi-Xue Zheng, Yu Sun, Yan-Hua Bai, Yun-Fei Shi, Li-Xin Zhou, Yun-Feng Yao, Ai-Wen Wu and Deng-Feng Cao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Special Scientific Research Key Project for Capital Health Development, China |
2018-2Z-1026 |
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| Corresponding Author |
Yu Sun, MD, PhD, Assistant Professor, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing 100142, China. sunyu_bch@163.com |
| Key Words |
Human epidermal growth factor receptor 2; Immunohistochemical staining; Fluorescent in situ hybridization; Prognosis; Colorectal cancers |
| Core Tip |
The manuscript investigated the prevalence of human epidermal growth factor receptor 2 (HER2) protein overexpression and gene amplification in a large series of surgically resected colorectal adenocarcinomas (CRCs), and evaluated their relationship with clinicopathological parameters and prognosis. We found that HER2 overexpression [immunohistochemical staining (IHC) score 2+ and 3+] is seen in a small percentage of colorectal adenocarcinomas and HER2 gene amplification occurs in the vast majority of tumors with 3+ IHC score but in a much lower percentage of tumors with 2+ IHC score. In addition, although the prevalence of HER2 overexpression by IHC in CRCs is low, HER2 protein status is correlated with clinical outcomes and positive HER2 expression by IHC confers a worse prognosis in 65 years or younger patients with tubular adenocarcinomas. |
| Publish Date |
2019-04-15 10:50 |
| Citation |
Wang XY, Zheng ZX, Sun Y, Bai YH, Shi YF, Zhou LX, Yao YF, Wu AW, Cao DF. Significance of HER2 protein expression and HER2 gene amplification in colorectal adenocarcinomas. World J Gastrointest Oncol 2019; 11(4): 335-347 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i4/335.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i4.335 |
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