Publication Name	World Journal of Hepatology
Manuscript ID	45419
Country	Romania

Received	2018-12-28 09:26
Peer-Review Started	2018-12-29 01:15
To Make the First Decision	2019-01-25 00:20
Return for Revision	2019-01-27 01:18
Revised	2019-02-22 16:21
Second Decision	2019-03-08 08:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-03-12 15:40
Articles in Press	2019-03-12 15:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-03-27 05:35
Publish the Manuscript Online	2019-03-27 10:37

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Observational Study
Article Title	Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study
Manuscript Source	Invited Manuscript
All Author List	Decebal Fodor, Ioan Jung, Sabin Turdean, Catalin Satala and Simona Gurzu
ORCID	Author(s) ORCID Number Decebal Fodor http://orcid.org/0000-0001-5949-8278 Ioan Jung http://orcid.org/0000-0001-6537-2807 Sabin Turdean http://orcid.org/0000-0001-7085-4755 Catalin Satala http://orcid.org/0000-0002-4466-6360 Simona Gurzu http://orcid.org/0000-0003-3968-5118
Funding Agency and Grant Number
Corresponding Author	Simona Gurzu, MD, PhD, Chief Doctor, Doctor, Full Professor, Professor, Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, 38 Gheorghe Marinescu Street, Targu Mures 540139, Romania. simonagurzu@yahoo.com
Key Words	Hepatocellular carcinoma; Angiogenesis; Endothelial area; Antiangiogenic therapy
Core Tip	In this paper we showed a possible role of morphological and immunohistochemical features of Hepatocellular carcinoma (HCC) in predicting the individualized antiangiogenic therapy of HCC. Based on the results and literature data, it seems that dedifferentiated HCCs developed in non-cirrhotic liver are predominantly driven via Cyclooxygenase-2 axis, whereas vascular endothelial growth factor-A induces hepatocarcinogenesis in patients with HCCs developed on the cirrhosis background.
Publish Date	2019-03-27 10:37
Citation	Fodor D, Jung I, Turdean S, Satala C, Gurzu S. Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study. World J Hepatol 2019; 11(3): 294-304
URL	https://www.wjgnet.com/1948-5182/full/v11/i3/294.htm
DOI	https://dx.doi.org/10.4254/wjh.v11.i3.294

Full Article (PDF)	WJH-11-294.pdf
Full Article (Word)	WJH-11-294.docx
Manuscript File	45419-Review.doc
Answering Reviewers	45419-Answering reviewers.pdf
Audio Core Tip	45419-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	45419-Conflict-of-interest statement.pdf
Copyright License Agreement	45419-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	45419-Institutional review board statement.pdf
Peer-review Report	45419-Peer-review(s).pdf
Scientific Misconduct Check	45419-Scientific misconduct check.pdf
Scientific Editor Work List	45419-Scientific editor work list.pdf