Publication Name	World Journal of Stem Cells
Manuscript ID	4573
Country	Iran

Received	2013-07-08 09:40
Peer-Review Started	2013-07-08 11:56
To Make the First Decision	2013-08-21 18:53
Return for Revision	2013-08-26 10:50
Revised	2013-08-31 18:21
Second Decision	2013-11-04 16:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-05 09:04
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-09 15:55
Typeset the Manuscript	2014-01-10 15:04
Publish the Manuscript Online	2014-02-15 15:06

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Review
Article Title	Dendritic cells derived from pluripotent stem cells: potential of large scale production
Manuscript Source	Invited Manuscript
All Author List	Yan Li, Meimei Liu and Shang-Tian Yang
Funding Agency and Grant Number
Corresponding Author	Alireza Khoshnevisan, Assistant Professor, Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Valie-Asr Str., Tehran 14174, Iran. akhoshnevisan@tums.ac.ir
Key Words	Pluripotent stem cells; dendritic cells; bioreactor; hematopoietic differentiation; large scale production
Core Tip	Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) are promising sources for hematopoietic cells. This review summarizes recent advances in differentiating hESCs and hiPSCs to dendritic cells (DCs), which are unique immune cells in the hematopoietic system and can be loaded with tumor specific antigen and used as vaccine for cancer immunotherapy. While autologous DCs from peripheral blood are limited in number, human PSC (hPSC)-derived DCs provide a novel alternative cell source for clinical application. Different strategies and effects of shear stress on large-scale production of hPSC-derived DCs in bioreactors are also discussed.
Publish Date	2014-02-15 15:06
Citation	Safari M, Khoshnevisan A. An overview of the role of cancer stem cells in spine tumors with a special focus on chordoma. World J Stem Cells 2014; 6(1): 53-64
URL	http://www.wjgnet.com/1948-0210/full/v6/i1/53.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i1.53

Full Article (PDF)	WJSC-6-53.pdf
Full Article (Word)	WJSC-6-53.doc
Manuscript File	4573-Review.docx
Answering Reviewers	4573-Answering reviewers.pdf
Copyright License Agreement	4573-Copyright assignment.pdf
Peer-review Report	4573-Peer reviewer(s).pdf
Scientific Editor Work List	4573-Scientific editor work list.doc