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3/14/2019 12:55:48 AM | Browse: 49 | Download: 20
Publication Name World Journal of Gastroenterology
Manuscript ID 45797
Country of Manuscript Source United States
Received
2019-01-17 01:48
Peer-Review Started
2019-01-18 05:43
To Make the First Decision
2019-01-31 04:38
Return for Revision
2019-01-31 08:28
Revised
2019-02-04 21:39
Second Decision
2019-02-22 09:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-02-23 05:12
Articles in Press
2019-02-23 05:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-13 00:39
Publish the Manuscript Online
2019-03-14 00:55
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Minireviews
Article Title Personalized medicine in functional gastrointestinal disorders: Understanding pathogenesis to increase diagnostic and treatment efficacy
Manuscript Source Invited Manuscript
All Author List Xiao Jing Wang and Michael Camilleri
ORCID
Author(s) ORCID Number
Xiao Jing Wang http://orcid.org/0000-0001-7842-1161
Michael Camilleri http://orcid.org/0000-0001-6472-7514
Funding Agency and Grant Number
Correspondence To Michael Camilleri, MD, Doctor, Professor, Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, 200 First St. S.W., Rochester, MN55905, United States. camilleri.michael@mayo.edu
Keywords Gastrointestinal symptoms; Gastric emptying; Gastric accommodation; Diarrhea; Constipation; Irritable bowel syndrome; Bile acid diarrhea; Phenotypes; Pharmacogenomics; Prokinetics; Neuromodulators
Core Tip Functional gastrointestinal disorders (FGIDs) are associated with mechanisms that constitute important targets for personalized treatment. Patients with upper gastrointestinal (GI) symptoms may have delayed gastric emptying (GE), reduced gastric accommodation (GA), both impaired GE and GA, or neither. Treatments targeted to the underlying pathophysiology utilize prokinetics, gastric relaxants, or central neuromodulators. Patients with functional lower GI symptoms may have constipation-predominant irritable bowel syndrome, pelvic floor dyssynergia, colonic inertia, diarrhea-predominant irritable bowel syndrome, bile acid diarrhea, or disaccharidase or sucrose-isomaltase deficiency. Personalization is applied through pharmacogenomics related to drug pharmacokinetics, specifically the role of CYP2D6, 2C19 and 3A4. The time for personalized treatments of FGIDs is here.
Publish Date 2019-03-14 00:55
Citation Wang XJ, Camilleri M. Personalized medicine in functional gastrointestinal disorders: Understanding pathogenesis to increase diagnostic and treatment efficacy. World J Gastroenterol 2019; 25(10): 1185-1196
Url https://www.wjgnet.com/1007-9327/full/v25/i10/1185.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i10.1185
Full Article (PDF) WJG-25-1185.pdf
Full Article (Word) WJG-25-1185.docx
Manuscript File 45797-Review.docx
Answering Reviewers 45797-Answering reviewers.pdf
Audio Core Tip 45797-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 45797-Conflict-of-interest statement.pdf
Copyright License Agreement 45797-Copyright license agreement.pdf
Peer-review Report 45797-Peer-review(s).pdf
Scientific Misconduct Check 45797-Google-MA RY-1.png
Scientific Misconduct Check 45797-Scientific misconduct check.pdf
Scientific Editor Work List 45797-Scientific editor work list.pdf