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Articles Published Processes
3/14/2019 12:55:48 AM | Browse: 1195 | Download: 2087
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Received |
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2019-01-17 01:48 |
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Peer-Review Started |
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2019-01-18 05:43 |
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To Make the First Decision |
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2019-01-31 04:38 |
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Return for Revision |
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2019-01-31 08:28 |
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Revised |
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2019-02-04 21:39 |
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Second Decision |
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2019-02-22 09:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-02-23 05:12 |
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Articles in Press |
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2019-02-23 05:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-03-13 00:39 |
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Publish the Manuscript Online |
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2019-03-14 00:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Personalized medicine in functional gastrointestinal disorders: Understanding pathogenesis to increase diagnostic and treatment efficacy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao Jing Wang and Michael Camilleri |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Michael Camilleri, MD, Doctor, Doctor, Professor, Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, 200 First St. S.W., Rochester, MN 55905, United States. camilleri.michael@mayo.edu |
| Key Words |
Gastrointestinal symptoms; Gastric emptying; Gastric accommodation; Diarrhea; Constipation; Irritable bowel syndrome; Bile acid diarrhea; Phenotypes; Pharmacogenomics; Prokinetics; Neuromodulators |
| Core Tip |
Functional gastrointestinal disorders (FGIDs) are associated with mechanisms that constitute important targets for personalized treatment. Patients with upper gastrointestinal (GI) symptoms may have delayed gastric emptying (GE), reduced gastric accommodation (GA), both impaired GE and GA, or neither. Treatments targeted to the underlying pathophysiology utilize prokinetics, gastric relaxants, or central neuromodulators. Patients with functional lower GI symptoms may have constipation-predominant irritable bowel syndrome, pelvic floor dyssynergia, colonic inertia, diarrhea-predominant irritable bowel syndrome, bile acid diarrhea, or disaccharidase or sucrose-isomaltase deficiency. Personalization is applied through pharmacogenomics related to drug pharmacokinetics, specifically the role of CYP2D6, 2C19 and 3A4. The time for personalized treatments of FGIDs is here. |
| Publish Date |
2019-03-14 00:55 |
| Citation |
Wang XJ, Camilleri M. Personalized medicine in functional gastrointestinal disorders: Understanding pathogenesis to increase diagnostic and treatment efficacy. World J Gastroenterol 2019; 25(10): 1185-1196 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i10/1185.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i10.1185 |
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