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4/25/2019 3:13:57 AM | Browse: 728 | Download: 913
Publication Name World Journal of Gastroenterology
Manuscript ID 45933
Country/Territory China
Received
2019-01-27 02:05
Peer-Review Started
2019-01-27 03:28
To Make the First Decision
2019-02-26 07:55
Return for Revision
2019-02-26 09:03
Revised
2019-03-07 01:53
Second Decision
2019-03-22 08:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-25 04:42
Articles in Press
2019-03-25 04:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-03-30 10:33
Typeset the Manuscript
2019-04-17 06:25
Publish the Manuscript Online
2019-04-25 03:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions
Manuscript Source Unsolicited Manuscript
All Author List Yang-Hui Bi, Wen-Qi Han, Ruo-Fei Li, Yun-Jiao Wang, Zun-Shu Du, Xue-Jiang Wang and Ying Jiang
ORCID
Author(s) ORCID Number
Yang-Hui Bi http://orcid.org/0000-0002-3039-6072
Wen-Qi Han http://orcid.org/0000-0003-3106-4210
Ruo-Fei Li http://orcid.org/0000-0001-6733-1486
Yun-Jiao Wang http://orcid.org/0000-0002-1778-5735
Zun-Shu Du http://orcid.org/0000-0002-1516-816X
Xue-Jiang Wang http://orcid.org/0000-0003-4772-7365
Ying Jiang http://orcid.org/0000-0001-5908-0904
Funding Agency and Grant Number
Funding Agency Grant Number
the Beijing Municipal Education Commission Research Program KM20160025004
the Beijing Natural Science Foundation of China 7102013
the National Natural Science Foundation of China 81070319
Corresponding Author Ying Jiang, PhD, Professor, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China. jiangy@ccmu.edu.cn
Key Words Warburg effect; Hepatic progenitor cell; Signal transducer and activator of transcription 3; Pyruvate kinase M2; Liver precancerous lesion
Core Tip Signal transducer and activator of transcription 3 (STAT3) is stimulated in hepatocellular carcinoma and regulates the Warburg effect in many tumors. However, whether the activation of STAT3 can enhance the Warburg effect is unclear in liver precancerous lesions. Here, we provide the evidence that the Warburg effect was enhanced in liver precancerous lesions in rats, perhaps through up-regulating the expression of pyruvate kinase M2 (PKM2) and p-STAT3 in activated oval cells. STAT3 activation promotes the Warburg effect by activing PKM2 in transformed WB-F344 cells induced with N-methyl-N’-nitro-N-nitrosoguanidine and hydrogen peroxide.
Publish Date 2019-04-25 03:13
Citation Bi YH, Han WQ, Li RF, Wang YJ, Du ZS, Wang XJ, Jiang Y. Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions. World J Gastroenterol 2019; 25(16): 1936-1949
URL https://www.wjgnet.com/1007-9327/full/v25/i16/1936.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i16.1936
Full Article (PDF) WJG-25-1936.pdf
Full Article (Word) WJG-25-1936.docx
The ARRIVE Guidelines 45933-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 45933-Review_Edited.doc
Answering Reviewers 45933-Answering reviewers.pdf
Audio Core Tip 45933-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 45933-Conflict-of-interest statement.pdf
Copyright License Agreement 45933-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 45933-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 45933-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 45933-Language certificate.pdf
Peer-review Report 45933-Peer-review(s).pdf
Scientific Misconduct Check 45933-Google-MA RY-1.png
Scientific Misconduct Check 45933-Google-MA RY-2.png
Scientific Misconduct Check 45933-Scientific misconduct check.pdf
Scientific Editor Work List 45933-Scientific editor work list.pdf