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Articles Published Processes
4/25/2019 3:13:57 AM | Browse: 852 | Download: 1432
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Received |
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2019-01-27 02:05 |
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Peer-Review Started |
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2019-01-27 03:28 |
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To Make the First Decision |
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2019-02-26 07:55 |
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Return for Revision |
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2019-02-26 09:03 |
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Revised |
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2019-03-07 01:53 |
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Second Decision |
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2019-03-22 08:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-25 04:42 |
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Articles in Press |
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2019-03-25 04:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-03-30 10:33 |
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Typeset the Manuscript |
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2019-04-17 06:25 |
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Publish the Manuscript Online |
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2019-04-25 03:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yang-Hui Bi, Wen-Qi Han, Ruo-Fei Li, Yun-Jiao Wang, Zun-Shu Du, Xue-Jiang Wang and Ying Jiang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Beijing Municipal Education Commission Research Program |
KM20160025004 |
| the Beijing Natural Science Foundation of China |
7102013 |
| the National Natural Science Foundation of China |
81070319 |
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| Corresponding Author |
Ying Jiang, PhD, Professor, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China. jiangy@ccmu.edu.cn |
| Key Words |
Warburg effect; Hepatic progenitor cell; Signal transducer and activator of transcription 3; Pyruvate kinase M2; Liver precancerous lesion |
| Core Tip |
Signal transducer and activator of transcription 3 (STAT3) is stimulated in hepatocellular carcinoma and regulates the Warburg effect in many tumors. However, whether the activation of STAT3 can enhance the Warburg effect is unclear in liver precancerous lesions. Here, we provide the evidence that the Warburg effect was enhanced in liver precancerous lesions in rats, perhaps through up-regulating the expression of pyruvate kinase M2 (PKM2) and p-STAT3 in activated oval cells. STAT3 activation promotes the Warburg effect by activing PKM2 in transformed WB-F344 cells induced with N-methyl-N’-nitro-N-nitrosoguanidine and hydrogen peroxide. |
| Publish Date |
2019-04-25 03:13 |
| Citation |
Bi YH, Han WQ, Li RF, Wang YJ, Du ZS, Wang XJ, Jiang Y. Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions. World J Gastroenterol 2019; 25(16): 1936-1949 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i16/1936.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i16.1936 |
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