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Articles Published Processes
5/28/2019 9:29:42 AM | Browse: 1142 | Download: 1725
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Received |
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2019-01-23 01:55 |
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Peer-Review Started |
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2019-01-23 08:16 |
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To Make the First Decision |
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2019-02-21 05:58 |
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Return for Revision |
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2019-02-21 08:44 |
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Revised |
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2019-03-06 08:58 |
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Second Decision |
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2019-03-22 08:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-25 04:44 |
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Articles in Press |
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2019-03-25 04:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-05-25 07:15 |
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Publish the Manuscript Online |
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2019-05-28 09:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Systematic review: Renin-angiotensin system inhibitors in chemoprevention of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Michele Barone, Maria Teresa Viggiani, Giuseppe Losurdo, Mariabeatrice Principi and Alfredo Di Leo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Michele Barone, MD, PhD, Adjunct Professor, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Piazza Giulio Cesare 11, Bari 70124, Italy. michele.barone@uniba.it |
| Key Words |
Cirrhosis; Renin; Angiotensin; Survival; Cancer prevention; Hepatocarcinoma |
| Core Tip |
All experimental studies strongly support the ability of renin-angiotensin system (RAS) inhibitors to counteract carcinogenesis essentially by inhibiting angiogenesis and possibly fibrogenesis in chemically-induced or xeno-transplanted hepatocarcinomas, whereas additional pathogenetic mechanisms using animal models that mimic the progression of liver disease in humans and have been barely considered. In all randomized clinical trials, RAS inhibitors - in combination with other therapies - significantly reduced cumulative hepatocarcinoma recurrence. However, the data on patient survival obtained by these studies and several observational studies are not conclusive. The beneficial effect of the early use of RAS inhibitors on the progression of cirrhosis toward hepatocarcinoma cannot be excluded. |
| Publish Date |
2019-05-28 09:29 |
| Citation |
Barone M, Viggiani MT, Losurdo G, Principi M, Di Leo A. Systematic review: Renin-angiotensin system inhibitors in chemoprevention of hepatocellular carcinoma. World J Gastroenterol 2019; 25(20): 2524-2538 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i20/2524.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i20.2524 |
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