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Articles Published Processes
3/15/2019 7:18:19 AM | Browse: 1172 | Download: 1540
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Received |
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2019-02-06 03:03 |
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Peer-Review Started |
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2019-02-10 14:42 |
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To Make the First Decision |
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2019-02-20 00:34 |
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Return for Revision |
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2019-02-21 04:25 |
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Revised |
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2019-03-08 20:08 |
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Second Decision |
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2019-03-12 09:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-12 23:10 |
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Articles in Press |
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2019-03-12 23:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-03-14 09:09 |
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Publish the Manuscript Online |
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2019-03-15 07:18 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Case Control Study |
| Article Title |
Screening the RFX6-DNA binding domain for potential genetic variants in patients with type 2 diabetes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ismail Sami Mahmoud, Ayat Homsi, Hamzeh Al-Ameer, Jihad Alzyoud, Mais Darras, Mohammad Al Shhab, Malek Zihlif, Ma’mon Hatmal and Walhan Alshaer |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ismail Sami Mahmoud, PhD, Doctor, Doctor, Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, The Hashemite University, Zarqa 13133, Jordan. ismails@hu.edu.jo |
| Key Words |
Regulatory factor X6; Genetic variant; Diabetes; DNA binding domain |
| Core Tip |
Regulatory Factor X6 (RFX6) protein plays a key role in the differentiation of pancreatic beta cells as well as insulin production and secretion. Several lines of evidence have indicated that RFX6 binding to DNA could be disrupted in diabetes; however, the mechanism underlying this process is still unknown. In this case-control study, we analysed the genotype of RFX6-DNA binding domain in diabetes patients in comparison to healthy controls. Our results indicate the absence of any significant genetic variant in the DNA binding domain that could affect the function of RFX6 in type 2 diabetes. |
| Publish Date |
2019-03-15 07:18 |
| Citation |
Mahmoud IS, Homsi A, Al-Ameer HJ, Alzyoud J, Darras M, Shhab MA, Zihlif M, Hatmal MM, Alshaer W. Screening the RFX6-DNA binding domain for potential genetic variants in patients with type 2 diabetes. World J Diabetes 2019; 10(3): 181-188 |
| URL |
https://www.wjgnet.com/1948-9358/full/v10/i3/181.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v10.i3.181 |
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