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Articles Published Processes
7/26/2019 12:39:36 AM | Browse: 857 | Download: 1510
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Received |
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2019-02-20 06:04 |
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Peer-Review Started |
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2019-02-22 08:59 |
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To Make the First Decision |
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2019-06-05 06:47 |
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Return for Revision |
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2019-06-06 04:03 |
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Revised |
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2019-06-18 11:02 |
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Second Decision |
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2019-06-20 04:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-06-27 19:46 |
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Articles in Press |
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2019-06-27 19:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-07-03 01:24 |
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Typeset the Manuscript |
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2019-07-25 03:05 |
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Publish the Manuscript Online |
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2019-07-26 00:39 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Targeting cancer stem cells in drug discovery: Current state and future perspectives
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fang-Yu Du, Qi-Fan Zhou, Wen-Jiao Sun and Guo-Liang Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Liaoning Province |
201602707 |
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| Corresponding Author |
Guo-Liang Chen, PhD, Professor, Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenhe District, Shenyang 110016, Liaoning Province, China. chenguoliang@syphu.edu.cn |
| Key Words |
Cancer stem cells; Cancer stem cell-related signaling pathways; Nano-drug delivery system; Immunotherapy; Mitochondrion; Immunotherapy |
| Core Tip |
The review aims to introduce the field of cancer stem cells (CSCs) and the important signaling pathways in CSCs and present approved inhibitors as well as candidate drugs. Due to the complexity of the crosstalk among various signaling pathways, current strategies involve the development of multitarget inhibitors, combination therapy and precision treatments based on the genetic characteristics of patients. Other methods targeting CSCs are introduced as well, including nano-drug delivery systems, mitochondrion targeting, hyperthermia, immunotherapy and CSC microenvironment targeting. However, this field still remains in its infancy, and considerable research will be required to produce mature products that can contribute to curing cancer. |
| Publish Date |
2019-07-26 00:39 |
| Citation |
Du FY, Zhou QF, Sun WJ, Chen GL. Targeting cancer stem cells in drug discovery: Current state and future perspectives. World J Stem Cells 2019; 11(7): 398-420 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i7/398.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i7.398 |
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