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7/26/2019 12:39:36 AM | Browse: 711 | Download: 1126
Publication Name World Journal of Stem Cells
Manuscript ID 46592
Country/Territory China
Received
2019-02-20 06:04
Peer-Review Started
2019-02-22 08:59
To Make the First Decision
2019-06-05 06:47
Return for Revision
2019-06-06 04:03
Revised
2019-06-18 11:02
Second Decision
2019-06-20 04:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-27 19:46
Articles in Press
2019-06-27 19:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-07-03 01:24
Typeset the Manuscript
2019-07-25 03:05
Publish the Manuscript Online
2019-07-26 00:39
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Review
Article Title Targeting cancer stem cells in drug discovery: Current state and future perspectives
Manuscript Source Invited Manuscript
All Author List Fang-Yu Du, Qi-Fan Zhou, Wen-Jiao Sun and Guo-Liang Chen
ORCID
Author(s) ORCID Number
Fang-Yu Du http://orcid.org/0000-0001-7975-7775
Qi-Fan Zhou http://orcid.org/0000-0002-5738-3511
Wen-Jiao Sun http://orcid.org/0000-0003-4566-0590
Guo-Liang Chen http://orcid.org/0000-0003-3674-5226
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Liaoning Province 201602707
Corresponding Author Guo-Liang Chen, PhD, Professor, Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenhe District, Shenyang 110016, Liaoning Province, China. chenguoliang@syphu.edu.cn
Key Words Cancer stem cells; Cancer stem cell-related signaling pathways; Nano-drug delivery system; Immunotherapy; Mitochondrion; Immunotherapy
Core Tip The review aims to introduce the field of cancer stem cells (CSCs) and the important signaling pathways in CSCs and present approved inhibitors as well as candidate drugs. Due to the complexity of the crosstalk among various signaling pathways, current strategies involve the development of multitarget inhibitors, combination therapy and precision treatments based on the genetic characteristics of patients. Other methods targeting CSCs are introduced as well, including nano-drug delivery systems, mitochondrion targeting, hyperthermia, immunotherapy and CSC microenvironment targeting. However, this field still remains in its infancy, and considerable research will be required to produce mature products that can contribute to curing cancer.
Publish Date 2019-07-26 00:39
Citation Du FY, Zhou QF, Sun WJ, Chen GL. Targeting cancer stem cells in drug discovery: Current state and future perspectives. World J Stem Cells 2019; 11(7): 398-420
URL https://www.wjgnet.com/1948-0210/full/v11/i7/398.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i7.398
Full Article (PDF) WJSC-11-398.pdf
Full Article (Word) WJSC-11-398.docx
Manuscript File 46592-Review_Edited.docx
Answering Reviewers 46592-Answering reviewers.pdf
Audio Core Tip 46592-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 46592-Conflict-of-interest statement.pdf
Copyright License Agreement 46592-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46592-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 46592-Language certificate.pdf
Peer-review Report 46592-Peer-review(s).pdf
Scientific Misconduct Check 46592-Scientific misconduct check.pdf
Scientific Editor Work List 46592-Scientific editor work list.pdf