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Articles Published Processes
8/26/2019 10:16:55 AM | Browse: 971 | Download: 1593
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Received |
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2019-02-18 09:56 |
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Peer-Review Started |
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2019-02-20 06:10 |
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To Make the First Decision |
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2019-06-05 06:41 |
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Return for Revision |
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2019-06-06 04:02 |
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Revised |
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2019-06-26 07:27 |
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Second Decision |
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2019-07-01 00:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-07-17 18:03 |
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Articles in Press |
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2019-07-17 18:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-08-22 12:28 |
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Publish the Manuscript Online |
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2019-08-26 10:16 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Anatomy & Morphology |
| Manuscript Type |
Review |
| Article Title |
Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis in vitro and in vivo: From biological characteristics to therapeutic mechanisms
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fei Yin, Wen-Ying Wang and Wen-Hua Jiang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Natural Science Foundation of Jilin Province of China |
20190201010JC |
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| Corresponding Author |
Wen-Hua Jiang, MD, Adjunct Professor, Dept Histol & Embryol, Basic Medical College of Jilin University, 126 Xinmin Street, Changchun 130021, Jilin Province, China. jiangwenhua468@163.com |
| Key Words |
Human umbilical cord mesenchymal stem cells; Liver fibrosis; Hepatocyte-like cells; Mechanism; Cell therapy; Paracrine effect |
| Core Tip |
Liver fibrosis is a major global health problem, for which no efficient therapy is available. Cell therapy, particularly involving human umbilical cord mesenchymal stem cells (known as hUC-MSCs), represents a promising therapeutic strategy, based mainly on the cells’ paracrine effects, transdifferentiation capacity and immunomodulatory function. In this review, we discuss the characteristics of hUC-MSCs, focusing on the possible mechanisms of these cells to ameliorate liver fibrosis, based upon evidence from in vitro and in vivo studies as well as ongoing clinical trials. This review also includes a discussion of the current status of the field and its future prospects. |
| Publish Date |
2019-08-26 10:16 |
| Citation |
Yin F, Wang WY, Jiang WH. Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis in vitro and in vivo: From biological characteristics to therapeutic mechanisms. World J Stem Cells 2019; 11(8):548-564 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i8/548.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i8.548 |
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