Publication Name	World Journal of Stem Cells
Manuscript ID	46727
Country	China

Received	2019-02-21 01:38
Peer-Review Started	2019-02-22 09:25
To Make the First Decision	2019-06-05 06:47
Return for Revision	2019-06-06 04:12
Revised	2019-06-12 08:00
Second Decision	2019-06-14 14:59
Accepted by Journal Editor-in-Chief	2019-06-15 01:29
Accepted by Executive Editor-in-Chief	2019-06-20 21:40
Articles in Press	2019-06-20 21:40
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-06-30 20:46
Typeset the Manuscript	2019-08-22 12:23
Publish the Manuscript Online	2019-08-26 10:16

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Review
Article Title	Linking stemness with colorectal cancer initiation, progression, and therapy
Manuscript Source	Invited Manuscript
All Author List	Deepak Narayanan Iyer, Wai-Yan Sin and Lui Ng
ORCID	Author(s) ORCID Number Deepak Narayanan Iyer http://orcid.org/0000-0002-8050-6647 Wai-Yan Sin http://orcid.org/0000-0003-2082-822X Lui Ng http://orcid.org/0000-0002-9010-2654
Funding Agency and Grant Number
Corresponding Author	Lui Ng, PhD, Research Assistant Professor, Department of Surgery, The University of Hong Kong, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong., Pokfulam NA, China. luing@hku.hk
Key Words	Cancer stem cell; Colorectal cancer; Tumor microenvironment; Metastasis; Extracellular matrix; Tumor heterogeneity
Core Tip	With the advancement of technology, the importance of deciphering the roles of stem cells in the normal and malignant intestinal biology has grown tremendously. Aided by several molecular and environmental factors, evidence suggests that the colorectal cancer stem cells exploit the intestinal cellular framework causing the development and spread of the disease, simultaneously promoting a poor prognosis through drug resistance and recurrence-based events. Only by a better understanding of the biology of these cells, can there be an improvement in the strategies associated with clinical monitoring and therapeutic targeting required for disease management.
Publish Date	2019-08-26 10:16
Citation	Iyer DN, Sin WY, Ng L. Linking stemness with colorectal cancer initiation, progression, and therapy. World J Stem Cells 2019; 11(8):519-534
URL	https://www.wjgnet.com/1948-0210/full/v11/i8/519.htm
DOI	https://dx.doi.org/10.4252/wjsc.v11.i8.519

Full Article (PDF)	WJSC-11-519.pdf
Full Article (Word)	WJSC-11-519.docx
Manuscript File	FP6888_de5_CE1MS-edit2.docx
Answering Reviewers	46727-Answering reviewers.pdf
Audio Core Tip	46727-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	46727-Conflict-of-interest statement.pdf
Copyright License Agreement	46727-Copyright license agreement.pdf
Peer-review Report	46727-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	46727-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	46727-Scientific misconduct check.pdf
Scientific Editor Work List	46727-Scientific editor work list.pdf
CrossCheck Report	46727-CrossCheck Report.pdf