| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Radiology, Nuclear Medicine & Medical Imaging |
| Manuscript Type |
Basic Study |
| Article Title |
Development and in vitro study of bi-specific magnetic resonance imaging molecular probe for hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Hong Ma, Shuang Wang, Si-Yun Liu, Kun Chen, Zhi-Yuan Wu, Deng-Feng Li, Yong-Tao Mi, Long-Bin Hu, Zhong-Wei Chen and Xin-Ming Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| CAMS Innovation Fund for Medical Sciences |
2016-I2M-1-001 |
| PUMC Youth Fund |
2017320010 |
| Chinese Academy of Medical Sciences Research Fund |
ZZ2016B01 |
| Beijing HopeRun Special Fund of Cancer Foundation of China |
LC2016B15 |
|
| Corresponding Author |
Xin-Ming Zhao, BM BCh, Chairman, Chief Doctor, Professor, Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. zhaoxinming@cicams.ac.cn |
| Key Words |
Hepatocellular carcinoma; Molecular imaging; Magnetic resonance imaging; Ultra-small superparamagnetic iron nanoparticles; Alpha-fetoprotein; Glypican-3 |
| Core Tip |
The singly targeting of existing hepatocellular carcinoma-targeted magnetic resonance imaging (HCC-targeted MRI) probes may weaken the detection efficiency as biomarker associated tumor heterogeneity. Here, double-antibody-labeled ultra-small superparamagnetic iron nanoparticles (USPIO) were synthesized to simultaneously target HCC markers of alpha- fetoprotein (AFP) and Glypican-3 (GPC3) antigens in Hepa1-6/GPC3 cells. Such probes showed higher cancer cell labeling efficiency than singly- or non-targeted USPIO probes by Prussian blue staining and in vitro MRI, indicating enhanced specificity and sensitivity of micro hepatocellular carcinoma (MHCC) MRI diagnosis. Meanwhile, USPIO with small core (~5 nm) and hydrodynamic size (~60 nm) after antibodies labelling may undergo slow phagocytosis, which could enhance liver tumor MRI contrast in the animal or clinical trial study. |
| Publish Date |
2019-06-28 12:22 |
| Citation |
Ma XH, Wang S, Liu SY, Chen K, Wu ZY, Li DF, Mi YT, Hu LB, Chen ZW, Zhao XM. Development and in vitro study of bi-specific magnetic resonance imaging molecular probe for hepatocellular carcinoma. World J Gastroenterol 2019; 25(24): 3030-3043 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i24/3030.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i24.3030 |
