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Articles Published Processes
6/21/2019 3:42:23 AM | Browse: 1215 | Download: 1708
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Received |
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2019-03-02 06:15 |
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Peer-Review Started |
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2019-03-02 12:24 |
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To Make the First Decision |
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2019-04-17 00:17 |
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Return for Revision |
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2019-04-17 03:26 |
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Revised |
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2019-04-24 12:45 |
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Second Decision |
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2019-05-08 08:21 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-05-08 16:15 |
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Articles in Press |
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2019-05-08 16:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-05-13 00:00 |
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Typeset the Manuscript |
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2019-06-19 05:47 |
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Publish the Manuscript Online |
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2019-06-21 03:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Role of epigenetics in the transformation of inflammation into colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhen-Hua Yang, Yan-Qi Dang and Guang Ji |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Guang Ji, MD, PhD, Chief Physician, Director, Director, Doctor, Doctor, Full Professor, Occupational Physician, Professor, Research Scientist, Teacher, Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai 200032, China. jiliver@vip.sina.com |
| Key Words |
Colorectal cancer; Inflammation; DNA methylation; Histone modification; LncRNA; MicroRNAs; Epigenetics |
| Core Tip |
Chronic inflammation can promote the occurrence and progression of colorectal cancer (CRC), drawing more attention to the role of pro-inflammatory cytokines and immune cells in the cancer. By regulating the expression of various inflammatory signaling pathways and pro-inflammatory cytokines, epigenetic inheritance not only participates in the transformation of inflammation into CRC, but also facilitates invasion, metastasis and drug resistance of CRC. Compared with gene mutation that is irreversible, epigenetic inheritance is reversible or can be altered by the intervention. Therefore, the tumor microenvironment can be regulated by modulating epigenetic modifications, which may be novel alternatives to prevent and treat CRC. |
| Publish Date |
2019-06-21 03:42 |
| Citation |
Yang ZH, Dang YQ, Ji G. Role of epigenetics in the transformation of inflammation into colorectal cancer. World J Gastroenterol 2019; 25(23): 2863-2877 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i23/2863.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i23.2863 |
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