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6/21/2019 3:42:23 AM | Browse: 237 | Download: 182
Publication Name World Journal of Gastroenterology
Manuscript ID 46843
Country/Territory China
2019-03-02 06:15
Peer-Review Started
2019-03-02 12:24
To Make the First Decision
2019-04-17 00:17
Return for Revision
2019-04-17 03:26
2019-04-24 12:45
Second Decision
2019-05-08 08:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-05-08 16:15
Articles in Press
2019-05-08 16:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-05-13 00:00
Typeset the Manuscript
2019-06-19 05:47
Publish the Manuscript Online
2019-06-21 03:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Role of epigenetics in the transformation of inflammation into colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Zhen-Hua Yang, Yan-Qi Dang and Guang Ji
Author(s) ORCID Number
Zhen-Hua Yang http://orcid.org/0000-0001-9844-6411
Yan-Qi Dang http://orcid.org/0000-0001-8651-6937
Guang Ji http://orcid.org/0000-0003-0842-3676
Funding Agency and Grant Number
Corresponding author Guang Ji, MD, PhD, Chief Physician, Director, Doctor, Full Professor, Occupational Physician, Professor, Research Scientist, Teacher, Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai 200032, China. jiliver@vip.sina.com
Keywords Colorectal cancer; Inflammation; DNA methylation; Histone modification; LncRNA; MicroRNAs; Epigenetics
Core Tip Chronic inflammation can promote the occurrence and progression of colorectal cancer (CRC), drawing more attention to the role of pro-inflammatory cytokines and immune cells in the cancer. By regulating the expression of various inflammatory signaling pathways and pro-inflammatory cytokines, epigenetic inheritance not only participates in the transformation of inflammation into CRC, but also facilitates invasion, metastasis and drug resistance of CRC. Compared with gene mutation that is irreversible, epigenetic inheritance is reversible or can be altered by the intervention. Therefore, the tumor microenvironment can be regulated by modulating epigenetic modifications, which may be novel alternatives to prevent and treat CRC.
Publish Date 2019-06-21 03:42
Citation Yang ZH, Dang YQ, Ji G. Role of epigenetics in the transformation of inflammation into colorectal cancer. World J Gastroenterol 2019; 25(23): 2863-2877
Url https://www.wjgnet.com/1007-9327/full/v25/i23/2863.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i23.2863
Full Article (PDF) WJG-25-2863.pdf
Full Article (Word) WJG-25-2863.docx
Manuscript File 46843-Review_Edited.docx
Answering Reviewers 46843-Answering reviewers.pdf
Audio Core Tip 46843-Audio core tip.wav
Conflict-of-Interest Disclosure Form 46843-Conflict-of-interest statement.pdf
Copyright License Agreement 46843-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 46843-Language certificate.pdf
Video 46843-Video.mp4
Peer-review Report 46843-Peer-review(s).pdf
Scientific Misconduct Check 46843-Scientific misconduct check.pdf
Scientific Editor Work List 46843-Scientific editor work list.pdf