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Articles Published Processes
11/15/2019 7:45:48 AM | Browse: 1002 | Download: 1934
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Received |
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2019-03-06 02:25 |
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Peer-Review Started |
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2019-03-08 03:26 |
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To Make the First Decision |
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2019-04-16 07:33 |
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Return for Revision |
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2019-05-09 09:34 |
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Revised |
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2019-07-27 13:42 |
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Second Decision |
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2019-09-12 10:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-09-12 21:33 |
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Articles in Press |
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2019-09-12 21:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-11-05 01:33 |
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Publish the Manuscript Online |
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2019-11-15 07:45 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Calponin 3 promotes invasion and drug resistance of colon cancer cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Vidhya A Nair, Noura Al-khayyal, Sivaramakrishnan Sivaperumal and Wael M Abdel-Rahman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wael M Abdel-Rahman, MD, PhD, Professor, Department of Medical Laboratory Sciences, College of Health Sciences and Environment and Cancer Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates. whassan@sharjah.ac.ae |
| Key Words |
β-Catenin; Calponin 3; Colon cancer; Epithelial-mesenchymal transition; Invasion; Metastasis |
| Core Tip |
We hypothesized that Calponin 3 (CNN3) could play a role in carcinogenesis based upon its known biological functions. We showed that it is expressed in colon and breast cancer cells and it was associated with the metastatic phenotype in colon cancer via upregulating mesenchymal markers. CNN3 also improved the sensitivity to chemotherapy in these tumors. We also showed that it is linked to other carcinogenic pathways, such as extracellular signal-regulated kinase 1/2, β-Catenin, mutant p53, c-Jun, and heat shock protein 60 in colorectal cancer. Thus, CNN3 is a promising biomarker in colon cancer. |
| Publish Date |
2019-11-15 07:45 |
| Citation |
Nair VA, Al-khayyal NA, Sivaperumal S, Abdel-Rahman WM. Calponin 3 promotes invasion and drug resistance of colon cancer cells. World J Gastrointest Oncol 2019; 11(11): 971-982 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i11/971.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i11.971 |
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