Publication Name	World Journal of Gastroenterology
Manuscript ID	46936
Country	China

Received	2019-02-28 01:07
Peer-Review Started	2019-03-01 05:15
First Decision by Editorial Office Director	2019-04-04 02:43
Return for Revision	2019-04-08 07:02
Revised	2019-04-22 10:47
Publication Fee Transferred
Second Decision by Editor	2019-04-30 09:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2019-05-03 12:03
Articles in Press	2019-05-03 12:03
Edit the Manuscript by Language Editor	2019-05-08 02:32
Typeset the Manuscript	2019-05-20 00:32
Publish the Manuscript Online	2019-05-20 09:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Electroacupuncture at ST36 modulates gastric motility via vagovagal and sympathetic reflexes in rats
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Jiang Lu, Zhi Yu, Yan He, Bin Xu and Yin Yin
ORCID	Author(s) ORCID Number Meng-Jiang Lu http://orcid.org/0000000186354659 Zhi Yu http://orcid.org/0000000291792618 Yan He http://orcid.org/0000-0002-9718-6483 Bin Xu http://orcid.org/0000000340063009 Yin Yin http://orcid.org/0000-0003-0516-7494
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No.81373749 National Natural Science Foundation of China No.81673883 National Natural Science Foundation of China No.81574071
Corresponding Author	Bin Xu, PhD, Professor, Key Laboratory of Integrated Acupuncture and Drugs Constructed, Nanjing University of Chinese Medicine, No. 138, Xianlin Road, Nanjing 210023, Jiangsu Province, China. xubin@njucm.edu.cn
Key Words	Gastric motility; Electroacupuncture; Vagovagal reflex; Sympathetic nerve; Rats
Core Tip	In this study, we measured intragastric pressure to observe the effect of electroacupuncture (EA) at ST36 on gastric motility at different time intervals. The role of the peripheral autonomic nervous system in EA was determined by the vagus nerve and splanchnic nerve severance model, as well as by detecting peripheral autonomic nerve discharge. M2/3 and β1/2 receptor knockout mouse models were further used to identify autonomic receptor subtypes specifically involved in the regulation of gastric motility. Finally, we studied the role of brainstem neurocircuits during EA at ST36 by detecting the dorsal motor nucleus of the vagus (DMV) neuron discharge and the effect of microinjection of γ-aminobutyric acid and glutamate to the DMV. Using these approaches, the role of vagovagal and sympathetic reflexes in regulating gastric motility by EA at ST36 was determined.
Publish Date	2019-05-20 09:05
Citation	Lu MJ, Yu Z, He Y, Yin Y, Xu B. Electroacupuncture at ST36 modulates gastric motility via vagovagal and sympathetic reflexes in rats. World J Gastroenterol 2019; 25(19): 2315-2326
URL	https://www.wjgnet.com/1007-9327/full/v25/i19/2315.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i19.2315

Full Article (PDF)	WJG-25-2315.pdf
Full Article (Word)	WJG-25-2315.docx