Publication Name	World Journal of Clinical Cases
Manuscript ID	47120
Country	Italy

Received	2019-03-12 03:44
Peer-Review Started	2019-03-15 01:57
To Make the First Decision	2019-04-18 03:26
Return for Revision	2019-04-19 06:25
Revised	2019-05-02 13:20
Second Decision	2019-05-22 09:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-05-23 12:58
Articles in Press	2019-05-23 12:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-06-05 15:30
Typeset the Manuscript	2019-07-22 02:46
Publish the Manuscript Online	2019-07-26 10:13

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Prospective Study
Article Title	Desimplification to multi-tablet antiretroviral regimens in human immunodeficiency virus-type 1 infected adults: A cohort study
Manuscript Source	Invited Manuscript
All Author List	Maria C Rossi, Walter O Inojosa, Giuseppe Battistella, Antonella Carniato, Francesca Farina, Mario Giobbia and Pier G Scotton
ORCID	Author(s) ORCID Number Maria C Rossi http://orcid.org/0000-0003-1570-0248 Walter O Inojosa http://orcid.org/0000-0002-5821-6512 Giuseppe Battistella http://orcid.org/0000-0002-7734-2661 Antonella Carniato http://orcid.org/0000-0003-2410-0877 Francesca Farina http://orcid.org/0000-0002-1350-9565 Mario Giobbia http://orcid.org/0000-0002-6499-6594 Pier G Scotton http://orcid.org/0000-0003-0573-0814
Funding Agency and Grant Number
Corresponding Author	Walter O Inojosa, MD, Doctor, Infectious Diseases Unit, Treviso Hospital, Piazza Ospedale 1, Treviso 31100, Italy. walteromar.inojosa@aulss2.veneto.it
Key Words	Fixed-dose coformulations; Fixed dose coformulation regimens; Multitablet regimens; Human immunodeficiency virus; Highly active antiretroviral therapy;
Core Tip	In a cohort of adults with suppressed human immunodeficiency virus-type 1 (HIV-1) viremia, the switch from fixed-dose coformulations to the corresponding multitablet regimens (MTRs) did not affect the effectiveness of antiretroviral therapy in terms of virological response and immunological recovery. Our data came from a well-established study population that was demographically representative of the Italian HIV-infected population, with very high levels of adherence and complete virological suppression. By involving patients in the decision to switch to a MTR for economic reasons, the magnitude of the potential clinical benefits from fixed dose coformulation regimens appears to be cancelled by the efficacy and tolerability of the antiretroviral drugs currently available in MTRs, even in a generic formulation, despite a small risk of drug discontinuation in patients who switched to MTRs because of mere convenience issues due to the number of tablets.
Publish Date	2019-07-26 10:13
Citation	Rossi MC, Inojosa WO, Battistella G, Carniato A, Farina F, Giobbia M, Fuser R, Scotton PG. Desimplification to multi-tablet antiretroviral regimens in human immunodeficiency virus-type 1 infected adults: A cohort study. World J Clin Cases 2019; 7(14): 1814-1824
URL	https://www.wjgnet.com/2307-8960/full/v7/i14/1814.htm
DOI	https://dx.doi.org/10.12998/wjcc.v7.i14.1814

Full Article (PDF)	WJCC-7-1814.pdf
Full Article (Word)	WJCC-7-1814.docx
Manuscript File	FP6870_de16_CE1MS-edit2-2.docx
Answering Reviewers	47120-Answering reviewers.pdf
Audio Core Tip	47120-Audio core tip.m4a
Biostatistics Review Certificate	47120-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	47120-Conflict-of-interest statement.pdf
Copyright License Agreement	47120-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	47120-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	47120-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	47120-Language certificate.pdf
Peer-review Report	47120-Peer-review(s).pdf
Scientific Misconduct Check	47120-Scientific misconduct check.pdf
Scientific Editor Work List	47120-Scientific editor work list.pdf