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11/5/2019 8:52:01 AM | Browse: 115 | Download: 45
Publication Name World Journal of Stem Cells
Manuscript ID 47161
Country/Territory South Korea
Received
2019-03-12 08:19
Peer-Review Started
2019-03-15 01:30
To Make the First Decision
2019-08-06 02:55
Return for Revision
2019-08-20 02:51
Revised
2019-09-02 06:49
Second Decision
2019-09-12 10:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-13 22:45
Articles in Press
2019-09-13 22:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-10-30 01:51
Publish the Manuscript Online
2019-11-05 08:52
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Research and Experimental Medicine
Manuscript Type Basic Study
Article Title Ameliorating liver fibrosis in an animal model using the secretome released from miR-122-transfected adipose-derived stem cells
Manuscript Source Unsolicited Manuscript
All Author List Kee-Hwan Kim, Jae Im Lee, Ok-Hee Kim, Ha-Eun Hong, Bong Jun Kwak, Ho Joong Choi, Joseph Ahn, Tae Yun Lee, Sang Chul Lee and Say-June Kim
ORCID
Author(s) ORCID Number
Kee-Hwan Kim http://orcid.org/0000-0001-6219-6027
Jae Im Lee http://orcid.org/0000-0002-4074-3904
Ok-Hee Kim http://orcid.org/0000-0002-9204-2587
Ha-Eun Hong http://orcid.org/0000-0002-4361-4809
Bong Jun Kwak http://orcid.org/0000-0003-2409-9386
Ho Joong Choi http://orcid.org/0000-0002-0862-098X
Joseph Ahn http://orcid.org/0000-0001-8528-4919
Tae Yun Lee http://orcid.org/0000-0002-4414-7958
Sang Chul Lee http://orcid.org/0000-0002-8681-7059
Say-June Kim http://orcid.org/0000-0001-5171-4837
Funding Agency and Grant Number
Funding Agency Grant Number
National Research Foundation of Korea NRF-2015R1D1A1A01060721
Corresponding author Say-June Kim, MD, PhD, Professor, Surgeon, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, South Korea. sayjunekim@gmail.com
Keywords Adipose-derived stem cells; Liver fibrosis; MicroRNAs; miR-122; Mesenchymal stem cells; Secretome
Core Tip We herein intended to determine the antifibrotic effects of the secretome released from miR-122-transfected adipose-derived stromal cells (miR-122-secretome). miR122-secrectome and naïve secretome were intravenously administered to the mice with liver fibrosis, respectively. miR122-secrectome infusion provided higher therapeutic potential in terms of reducing collagen content in the liver, inhibiting proinflammatory cytokines, and reducing abnormally elevated liver enzymes than the infusion of the naïve secretome. Proteomic analysis of the miR122-secrectome indicated that the contents of antifibrotic proteins were significantly elevated compared to those in the naïve secretome. Our results demonstrate that miR122-secrectome has higher antifibrotic and anti-inflammatory properties than the naïve secretome.
Publish Date 2019-11-05 08:52
Citation Kim KH, Lee JI, Kim OH, Hong HE, Kwak BJ, Choi HJ, Ahn J, Lee TY, Lee SC, Kim SJ. Ameliorating liver fibrosis in an animal model using the secretome released from miR-122-transfected adipose-derived stem cells. World J Stem Cells 2019; 11(11):990-1004
Url https://www.wjgnet.com/1948-0210/full/v11/i11/990.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i11.990
Full Article (PDF) WJSC-11-990.pdf
Full Article (Word) WJSC-11-990.docx
Manuscript File 47161-Review.docx
Answering Reviewers 47161-Answering reviewers.pdf
Audio Core Tip 47161-Audio core tip.mp3
Biostatistics Review Certificate 47161-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 47161-Conflict-of-interest statement.pdf
Copyright License Agreement 47161-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 47161-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 47161-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 47161-Language certificate.pdf
Peer-review Report 47161-Peer-review(s).pdf
Scientific Misconduct Check 47161-Scientific misconduct check.pdf
Scientific Editor Work List 47161-Scientific editor work list.pdf