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8/6/2019 11:50:46 AM | Browse: 791 | Download: 965
Publication Name World Journal of Clinical Cases
Manuscript ID 47382
Country/Territory France
Received
2019-03-17 09:24
Peer-Review Started
2019-03-18 11:56
To Make the First Decision
2019-05-21 00:41
Return for Revision
2019-05-21 06:41
Revised
2019-06-18 11:14
Second Decision
2019-06-20 04:08
Accepted by Journal Editor-in-Chief
2019-06-22 00:46
Accepted by Company Editor-in-Chief
2019-06-27 06:34
Articles in Press
2019-06-27 06:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-07-13 18:45
Typeset the Manuscript
2019-07-22 08:47
Publish the Manuscript Online
2019-08-06 11:50
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Minireviews
Article Title Extrahepatic hepcidin production: The intriguing outcomes of recent years
Manuscript Source Invited Manuscript
All Author List Raed Daher, Thibaud Lefebvre, Hervé Puy and Zoubida Karim
ORCID
Author(s) ORCID Number
Raed Daher http://orcid.org/0000-0002-2333-9715
Thibaud Lefebvre http://orcid.org/0000-0003-1398-6473
Hervé Puy http://orcid.org/0000-0003-3362-2634
Zoubida Karim http://orcid.org/0000-0002-3724-5592
Funding Agency and Grant Number
Corresponding Author Zoubida Karim, PhD, Academic Research, Professor, Research Scientist, Senior Researcher, Université Paris Diderot, Faculté de médecine Site Bichat, 16 rue Henri-Huchard, Paris 75018, France. zoubida.karim@inserm.fr
Key Words Hepcidin; Extrahepatic hepcidin; Iron metabolism; Bacterial infection; Inflammation;
Core Tip Hepcidin is the key regulator of iron homeostasis and is involved in iron-related disorders, namely anemia of inflammation and primary and secondary hemochromatosis. Since the discovery of its hyposideremic role, considerable efforts were made to explore iron handling by hepcidin. Almost all these studies focused on the liver since this organ was shown to be the major source of systemic hepcidin. However, interesting pending data showed an extrahepatic production of hepcidin in several organs, but the involvement of this peripheral hepcidin in local and overall iron homeostasis remains unknown. Thus, we think that scientific community in the field should: (1) Consider the presence of endogenous hepcidin in the peripheral organs; and (2) Be interested in the involvement of hepcidin in other physiological and pathological mechanisms than systemic iron metabolism, in particular antimicrobial activity, acid secretion regulation, immune inflammatory response,…
Publish Date 2019-08-06 11:50
Citation Daher R, Lefebvre T, Puy H, Karim Z. Extrahepatic hepcidin production: The intriguing outcomes of recent years. World J Clin Cases 2019; 7(15):1926-1936
URL https://www.wjgnet.com/2307-8960/full/v7/i15/1926.htm
DOI https://dx.doi.org/10.12998/wjcc.v7.i15.1926
Full Article (PDF) WJCC-7-1926.pdf
Full Article (Word) WJCC-7-1926.docx
Manuscript File FP6899_de16_CE1MS_edit2.docx
Answering Reviewers 47382-Answering reviewers.pdf
Audio Core Tip 47382-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 47382-Conflict-of-interest statement.pdf
Copyright License Agreement 47382-Copyright license agreement.pdf
Peer-review Report 47382-Peer-review(s).pdf
Scientific Misconduct Check 47382-Scientific misconduct check.pdf
Scientific Editor Work List 47382-Scientific editor work list.pdf