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Articles Published Processes
8/6/2019 11:50:46 AM | Browse: 935 | Download: 1279
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Received |
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2019-03-17 09:24 |
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Peer-Review Started |
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2019-03-18 11:56 |
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To Make the First Decision |
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2019-05-21 00:41 |
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Return for Revision |
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2019-05-21 06:41 |
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Revised |
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2019-06-18 11:14 |
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Second Decision |
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2019-06-20 04:08 |
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Accepted by Journal Editor-in-Chief |
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2019-06-22 00:46 |
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Accepted by Executive Editor-in-Chief |
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2019-06-27 06:34 |
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Articles in Press |
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2019-06-27 06:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-07-13 18:45 |
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Typeset the Manuscript |
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2019-07-22 08:47 |
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Publish the Manuscript Online |
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2019-08-06 11:50 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Extrahepatic hepcidin production: The intriguing outcomes of recent years
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Raed Daher, Thibaud Lefebvre, Hervé Puy and Zoubida Karim |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zoubida Karim, PhD, Academic Research, Professor, Research Scientist, Senior Researcher, Université Paris Diderot, Faculté de médecine Site Bichat, 16 rue Henri-Huchard, Paris 75018, France. zoubida.karim@inserm.fr |
| Key Words |
Hepcidin; Extrahepatic hepcidin; Iron metabolism; Bacterial infection; Inflammation; |
| Core Tip |
Hepcidin is the key regulator of iron homeostasis and is involved in iron-related disorders, namely anemia of inflammation and primary and secondary hemochromatosis. Since the discovery of its hyposideremic role, considerable efforts were made to explore iron handling by hepcidin. Almost all these studies focused on the liver since this organ was shown to be the major source of systemic hepcidin. However, interesting pending data showed an extrahepatic production of hepcidin in several organs, but the involvement of this peripheral hepcidin in local and overall iron homeostasis remains unknown. Thus, we think that scientific community in the field should: (1) Consider the presence of endogenous hepcidin in the peripheral organs; and (2) Be interested in the involvement of hepcidin in other physiological and pathological mechanisms than systemic iron metabolism, in particular antimicrobial activity, acid secretion regulation, immune inflammatory response,… |
| Publish Date |
2019-08-06 11:50 |
| Citation |
Daher R, Lefebvre T, Puy H, Karim Z. Extrahepatic hepcidin production: The intriguing outcomes of recent years. World J Clin Cases 2019; 7(15):1926-1936 |
| URL |
https://www.wjgnet.com/2307-8960/full/v7/i15/1926.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v7.i15.1926 |
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