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Articles Published Processes
7/6/2019 6:23:58 AM | Browse: 746 | Download: 1221
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Received |
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2019-03-14 02:49 |
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Peer-Review Started |
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2019-03-14 06:44 |
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To Make the First Decision |
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2019-04-11 08:22 |
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Return for Revision |
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2019-04-12 02:04 |
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Revised |
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2019-05-05 06:36 |
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Second Decision |
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2019-05-30 08:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-06-01 13:19 |
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Articles in Press |
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2019-06-01 13:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-07-02 07:43 |
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Publish the Manuscript Online |
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2019-07-06 06:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Botulinum toxin injections after surgery for Hirschsprung disease: Systematic review and meta-analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Daniëlle Roorda, Zarah AM Abeln, Jaap Oosterlaan, Lodewijk WE van Heurn and Joep PM Derikx |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Daniëlle Roorda, BSc, MD, Research Associate, Department of Pediatric Surgery, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam Reproduction and Development, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands. d.roorda@amc.uva.nl |
| Key Words |
Hirschsprung disease; Botulinum toxin; Internal anal sphincter; Obstructive symptoms; Enterocolitis; Adverse effects |
| Core Tip |
Patients with obstructive symptoms after surgery for Hirschsprung disease can benefit from intra-sphincteric botulinum toxin injections. This study indicates that Botulinum toxin injections are effective in treating obstructive symptoms after surgery for Hirschsprung disease and were associated with mild and temporary adverse effects. The proportion of patients that benefited from botulinum toxin injections was significantly higher within one month after administration (79%) compared to longer follow-up (46%). Beneficial effect was temporary and lasted on average 6 mo, therefore requiring on average 2-3 injections per patient before satisfactory clinical improvement was achieved. |
| Publish Date |
2019-07-06 06:23 |
| Citation |
Roorda D, Abeln ZAM, Oosterlaan J, van Heurn LWE, Derikx JPM. Botulinum toxin injections after surgery for Hirschsprung disease: Systematic review and meta-analysis. World J Gastroenterol 2019; 25(25): 3268-3280 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i25/3268.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i25.3268 |
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