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6/14/2019 9:34:51 AM | Browse: 846 | Download: 1454
Publication Name World Journal of Gastroenterology
Manuscript ID 47395
Country China
Received
2019-03-14 01:38
Peer-Review Started
2019-03-14 07:06
To Make the First Decision
2019-03-27 05:37
Return for Revision
2019-03-27 09:13
Revised
2019-04-04 13:25
Second Decision
2019-04-28 09:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-04-29 10:15
Articles in Press
2019-04-29 10:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-05-04 22:56
Typeset the Manuscript
2019-06-13 08:26
Publish the Manuscript Online
2019-06-14 09:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which selected by an in-house editor and fully peer-reviewed by external reviewers. It distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Clinical Trials Study
Article Title Effects of early enteral nutrition on Th17/Treg and IL-23/IL-17 in septic patients
Manuscript Source Unsolicited Manuscript
All Author List Jia-Kui Sun, Wen-Hao Zhang, Wen-Xiu Chen, Xiang Wang and Xin-Wei Mu
ORCID
Author(s) ORCID Number
Jia-Kui Sun http://orcid.org/0000-0002-1248-7974
Wen-Hao Zhang http://orcid.org/0000-0003-2708-2221
Wen-Xiu Chen http://orcid.org/0000-0002-4692-487X
Xiang Wang http://orcid.org/0000-0002-0228-0152
Xin-Wei Mu http://orcid.org/0000-0002-1916-6567
Funding Agency and Grant Number
Funding Agency Grant Number
the National Natural Science Foundation of China No. 81701881
the Nanjing Medical Science and Technology Development Foundation No. YKK15098
the Nanjing Medical Science and Technology Development Foundation No. YKK17102
Corresponding Author Xiang Wang, MD, Doctor, Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical Universit, 68 Changle Road, Nanjing 210006, Jiangsu Province, China. njdrwx2016@163.com
Key Words Early enteral nutrition; Enteral nutrition; T helper lymphocytes; Th17/Treg cells; IL-23/IL-17 axis; Sepsis
Core Tip The aim of this prospective clinical trial was to investigate effects of early enteral nutrition (EEN) on Th17/Treg ratios and IL-23/IL-17 axis in septic patients. Patients were randomly divided into EEN or delayed enteral nutrition (DEN) groups. As a result, the Th17 percentages, Th17/Treg ratios, IL-17, IL-23, and IL-6 levels of the EEN group were lower than those of the DEN group on the 7th day after admission. In other words, EEN could regulate the imbalance of Th17/Treg ratios and suppress the IL-23/IL-17 axis during sepsis. Moreover, EEN could reduce the clinical severity but did not reduce the 28-d mortality of sepsis.
Publish Date 2019-06-14 09:34
Citation Sun JK, Zhang WH, Chen WX, Wang X, Mu XW. Effects of early enteral nutrition on Th17/Treg and IL-23/IL-17 in septic patients. World J Gastroenterol 2019; 25(22): 2799-2808
URL https://www.wjgnet.com/1007-9327/full/v25/i22/2799.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i22.2799
Full Article (PDF) WJG-25-2799.pdf
Full Article (Word) WJG-25-2799.docx
CONSORT 2010 Statement 47395-CONSORT-2010-Statement-revision.pdf
Manuscript File 47395-Review_Edited.doc
Answering Reviewers 47395-Answering reviewers.pdf
Audio Core Tip 47395-Audio core tip.m4a
Biostatistics Review Certificate 47395-Biostatistics statement.pdf
Clinical Trial Registration Statement 47395-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 47395-Conflict-of-interest statement.pdf
Copyright License Agreement 47395-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47395-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 47395-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 47395-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 47395-Language certificate.pdf
Peer-review Report 47395-Peer-review(s).pdf
Scientific Misconduct Check 47395-Scientific misconduct check.pdf
Scientific Editor Work List 47395-Scientific editor work list.pdf